ReviewIndian pacing and electrophysiology journal
Efficacy and safety of leadless pacemaker: A systematic review, pooled analysis and meta-analysis.
Review in Indian pacing and electrophysiology journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review and Meta-Analysis of Acute Mortality and Complication Rates Following Leadless Pacemaker Placement Using National-Level Data.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The Effectiveness and Safety of Leadless Pacemakers: An Updated Meta-Analysis.Current cardiology reports · 2024Pooled it
- Atrial leadless device dislodgment and intracardiac echocardiogram (ICE)-guided device retrieval after leadless pacemaker implantation: A case report.Journal of cardiology cases · 2026Article
- Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses.Annals of medicine · 2025Observational
- Comparison of readmission outcomes and complications between leadless and traditional transvenous pacemakers in older adults: a nationwide readmission analysis of 49852 admission events.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- From Technical Pitfall to Clinical Consequences: Leadless Pacing as a Rescue Solution.Reports (MDPI) · 2025Article
- Safety of Leadless Pacemaker Insertion in Nonagenarians.The Journal of innovations in cardiac rhythm management · 2025Article
- A case of severe tricuspid regurgitation with rupture of tricuspid valve chordae tendineae caused by leadless pacemaker implantation.HeartRhythm case reports · 2025Article
- Comparative safety of transvenous and leadless pacemakers in patients with cardiovascular diseases: A meta-analysis study.Heliyon · 2025Article
- Implantable Cardiac Devices in Patients with Brady- and Tachy-Arrhythmias: An Update of the Literature.Reviews in cardiovascular medicine · 2024Review
- A simultaneous occurrence of pulmonary embolism and cerebral infarction following Micra™ leadless pacemaker implantation.Journal of geriatric cardiology : JGC · 2023Article
- Comparison of in-hospital outcomes and complications of leadless pacemaker and traditional transvenous pacemaker implantation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Initial studies on the implanting sites of high and low ventricular septa using leadless cardiac pacemakers.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
- Leadless pacemaker implantation and azygos continuation in the inferior vena cava: a case description.Quantitative imaging in medicine and surgery · 2023Article
- Strategies for Safe Implantation and Effective Performance of Single-Chamber and Dual-Chamber Leadless Pacemakers.Journal of clinical medicine · 2023Review
- Is Less Always More? A Prospective Two-Centre Study Addressing Clinical Outcomes in Leadless versus Transvenous Single-Chamber Pacemaker Recipients.Journal of clinical medicine · 2022Article
- The knowns and unknowns of leadless pacing in 2022.Indian pacing and electrophysiology journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeadless pacemakers have been designed as an alternative to transvenous systems which avoid some of the complications associated with transvenous devices. We aim to perform a systematic review of the literature to report the safety and efficacy findings of leadless pacemakers.
methodsWe searched MEDLINE and EMBASE to identify studies reporting the safety, efficacy and outcomes of patients implanted with a leadless pacemaker. The pooled rate of adverse events was determined and random-effects meta-analysis was performed to compare rates of adverse outcomes for leadless compared to transvenous pacemakers.
resultsA total of 18 studies were included with 2496 patients implanted with a leadless pacemaker and success rates range between 95.5 and 100%. The device or procedure related death rate was 0.3% while any complication and pericardial tamponade occurred in 3.1% and 1.4% of patients, respectively. Other complications such as pericardial effusion, device dislodgement, device revision, device malfunction, access site complications and infection occurred in less than 1% of patients. Meta-analysis of four studies suggests that there was no difference in hematoma (RR 0.67 95%CI 0.21-2.18, 3 studies), pericardial effusion (RR 0.59 95%CI 0.15-2.25, 3 studies), device dislocation (RR 0.33 95%CI 0.06-1.74, 3 studies), any complication (RR 0.44 95%CI 0.17-1.09, 4 studies) and death (RR 0.45 95%CI 0.15-1.35, 2 studies) comparing patients who received leadless and transvenous pacemakers.
conclusionLeadless pacemakers are safe and effective for patients who have an indication for single chamber ventricular pacing and the findings appear to be comparable to transvenous pacemakers.
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