ArticleNeuron2022
Detailed mapping of behavior reveals the formation of prelimbic neural ensembles across operant learning.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Graph theory identifies altered prefrontal microcircuit organization in Shank3 mice, a mouse Model of autism.Cell reports · 2026Article
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- Graph Theory Identifies Autistic Patterns in the Prefrontal Circuit of a Mouse Model of Autism.Research square · 2026Article
- Prefrontal cortical deficits are a putative susceptibility factor for PTSD.Frontiers in behavioral neuroscience · 2026Article
- A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behavior.bioRxiv : the preprint server for biology · 2025Article
- Low-dimensional signatures of neuronal activity associated with long-term operant conditioning in Aplysia.Communications biology · 2025Article
- Distinct prelimbic cortex ensembles encode response execution and inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration.Addiction neuroscience · 2025Article
- Drug Self-Administration, Drug-Specific Behaviors, and Neurobehavioral Deep Learning Analyses.Addiction neuroscience · 2025Article
- Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking.bioRxiv : the preprint server for biology · 2025Article
- Transformations in prefrontal ensemble activity underlying rapid threat avoidance learning.Current biology : CB · 2025Article
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- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods.Current protocols · 2025Article
- Individual differences in prelimbic neural representation of food and cocaine seeking.Cell reports · 2024Article
- Minibox: Custom solo or semi-group housing chambers for long term housing of rats with miniscopes.MethodsX · 2024Article
- Neuropathic pain has sex-specific effects on oxycodone-seeking and non-drug-seeking ensemble neurons in the dorsomedial prefrontal cortex of mice.Addiction biology · 2024Article
- Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning.Addiction neuroscience · 2024Article
- Article
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Authors and funding
10 authors.
Funding
Abstract
The prelimbic cortex (PrL) is involved in the organization of operant behaviors, but the relationship between longitudinal PrL neural activity and operant learning and performance is unknown. Here, we developed deep behavior mapping (DBM) to identify behavioral microstates in video recordings. We combined DBM with longitudinal calcium imaging to quantify behavioral tuning in PrL neurons as mice learned an operant task. We found that a subset of PrL neurons were strongly tuned to highly specific behavioral microstates, both task and non-task related. Overlapping neural ensembles were tiled across consecutive microstates in the response-reinforcer sequence, forming a continuous map. As mice learned the operant task, weakly tuned neurons were recruited into new ensembles, with a bias toward behaviors similar to their initial tuning. In summary, our data suggest that the PrL contains neural ensembles that jointly encode a map of behavioral states that is fine grained, is continuous, and grows during operant learning.
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