ArticleIntensive care medicine2022
Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis.
Article in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06868823 (LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation), which is not on this map. Cited by 130 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation: A Prospective, Observational, and Pilot Study
Who cites it
130 citing papers in PubMed, 8 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- Anticoagulation Strategies in Adults Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis.Artificial organs · 2026Pooled it
- Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Guideline
- Efficacy of reduced-intensity or no heparin versus standard heparin anticoagulation in patients on extracorporeal membrane oxygenation: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Meta-Analysis of Durable Compared to Temporary Left Ventricular Assist Devices Compared to Venoarterial Extracorporeal Membrane Oxygenation for Bridging to Heart Transplantation or Treatment of Primary Graft Dysfunction.Reviews in cardiovascular medicine · 2025Pooled it
- British societies guideline on the management of emergencies in patients on extracorporeal membrane oxygenation.Intensive care medicine · 2025Guideline
- Risk factors for neurological complications in adult ECMO patients: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- [Extracorporeal Membrane Oxygenation in Complex Tracheobronchial Surgery: A Series Case Reports and Systematic Review].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Pooled it
- Assessing Venous Thrombotic Risks in Extracorporeal Membrane Oxygenation-Supported Patients: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Trial
- Effect of Unfractionated Heparin Dose on Complement Activation and Selected Extracellular Vesicle Populations during Extracorporeal Membrane Oxygenation.International journal of molecular sciences · 2024Trial
- A Review of the Role of Artificial Intelligence in Patients on Extracorporeal Membrane Oxygenation: A Scoping Review Study.Health science reports · 2026Review
- Identification of Coagulation Phenotypes Using Viscoelastic and Conventional Assays During Veno-Venous Extracorporeal Membrane Oxygenation: A Hierarchical Clustering Analysis.Artificial organs · 2026Observational
- A best evidence summary of anticoagulation management for extracorporeal membrane oxygenation in adults.Medicine · 2026Article
- Standardization ofPerfusion · 2026Review
- Thrombin generation parameters provide independent information on plasma coagulation potential in pediatric patients on extracorporeal membrane oxygenation: a prospective, single-center pilot study.Research and practice in thrombosis and haemostasis · 2026Observational
- Gastrointestinal bleeding in patients on venoarterial extracorporeal membrane oxygenation: a multicenter observational study.BMC gastroenterology · 2026Observational
- Stroke Subtype as a Determinant of Mortality in Adult Patients on Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2026Article
- Digital performance testing reveals how redesigned return cannulas can enhance VV-ECMO performance.Intensive care medicine experimental · 2026Article
- Intestinal Ischaemia and Perforation After Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) for Acute Exacerbation of Interstitial Lung Disease: An Autopsy Case.Respirology case reports · 2026Article
- Extracorporeal Membrane Oxygenation in Refractory Cardiac Arrest: Current Evidence, Clinical Pathways and Future Directions.Life (Basel, Switzerland) · 2026Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
purposeThis study aimed at analyzing the prevalence, mortality association, and risk factors for bleeding and thrombosis events (BTEs) among adults supported with venovenous extracorporeal membrane oxygenation (VV-ECMO).
methodsWe queried the Extracorporeal Life Support Organization registry for adults supported with VV-ECMO from 2010 to 2017. Multivariable logistic regression modeling was used to assess the association between BTEs and in-hospital mortality and the predictors of BTEs.
resultsAmong 7579 VV-ECMO patients meeting criteria, 40.2% experienced ≥ 1 BTE. Thrombotic events comprised 54.9% of all BTEs and were predominantly ECMO circuit thrombosis. BTE rates decreased significantly over the study period (p < 0.001). The inpatient mortality rate was 34.9%. Bleeding events (1.69 [1.49-1.93]) were more strongly associated with in-hospital mortality than thrombotic events (1.23 [1.08-1.41]) p < 0.01 for both. The BTEs most strongly associated with mortality were ischemic stroke (4.50 [2.55-7.97]) and medical bleeding, including intracranial (5.71 [4.02-8.09]), pulmonary (2.02 [1.54-2.67]), and gastrointestinal (1.54 [1.2-1.98]) hemorrhage, all p < 0.01. Risk factors for bleeding included acute kidney injury and pre-ECMO vasopressor support and for thrombosis were higher weight, multisite cannulation, pre-ECMO arrest, and higher PaCO
conclusionsAlthough decreasing over time, BTEs remain common during VV-ECMO and have a strong, cumulative association with in-hospital mortality. Thrombotic events are more frequent, but bleeding carries a higher risk of inpatient mortality. Differential risk factors for bleeding and thrombotic complications exist, raising the possibility of a tailored approach to VV-ECMO management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.