ArticleHuman brain mapping2022
Patients with chronic pain exhibit individually unique cortical signatures of pain encoding.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A multi-ancestry genetic study of pain intensity in 598,339 veterans.Nature medicine · 2024Pooled it
- A coordinate-based meta-analysis of acupuncture for chronic pain: Evidence from fMRI studies.Frontiers in neuroscience · 2022Pooled it
- Impact of Intermittent Theta Burst Stimulation on Pain Relief and Brain Connectivity in Chronic Low Back Pain.European journal of pain (London, England) · 2025Trial
- The hijacked insula: A stratified model of affective touch modulation in chronic pain.Journal of neuropsychology · 2026Review
- Brain dysconnectivity patterns associated with chronic back pain development.Brain informatics · 2026Article
- Machine Learning-Derived Neural Signatures of Itch and Pain That Reliably Distinguish the Two Sensations in Humans: A Proof-Of-Concept Study.European journal of pain (London, England) · 2026Article
- Personalized brain decoding of spontaneous pain in individuals with chronic pain.Nature neuroscience · 2026Article
- The Impact of Brain Morphometry on Low Back Pain Risk: A Mendelian Randomization Study.Journal of pain research · 2026Article
- A cross-sectional analysis of brain structure, pain behaviors, and mental health in persons with surgically confirmed endometriosis.Communications biology · 2025Article
- Perfusion dynamics in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2025Article
- Article
- Cerebral morphometric alterations predict the outcome of migraine diagnosis and subtyping: a radiomics analysis.BMC medical imaging · 2025Article
- Assessing the Modulatory Effects of tDCS and Acupuncture on Cerebral Blood Flow in Chronic Low Back Pain Using Arterial Spin Labeling Perfusion Imaging.Brain sciences · 2025Article
- Article
- Shallow Acupuncture for Chronic Neck Pain: A Multicenter Randomized Controlled Trial Protocol with fMRI and DTI.Journal of pain research · 2025Article
- Reduced Cortical Surface Area in the Frontal Operculum as a Causal Risk Predictor for Chronic Pain.Pain research & management · 2025Article
- The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response.Journal of pain research · 2025Article
- Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.The journal of headache and pain · 2024Article
- Statistical learning shapes pain perception and prediction independently of external cues.eLife · 2024Article
- Uncovering brain functional connectivity disruption patterns of lung cancer-related pain.Brain imaging and behavior · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain is characterised by an ongoing and fluctuating intensity over time. Here, we investigated how the trajectory of the patients' endogenous pain is encoded in the brain. In repeated functional MRI (fMRI) sessions, 20 patients with chronic back pain and 20 patients with chronic migraine were asked to continuously rate the intensity of their endogenous pain. Linear mixed effects models were used to disentangle cortical processes related to pain intensity and to pain intensity changes. At group level, we found that the intensity of pain in patients with chronic back pain is encoded in the anterior insular cortex, the frontal operculum, and the pons; the change of pain in chronic back pain and chronic migraine patients is mainly encoded in the anterior insular cortex. At the individual level, we identified a more complex picture where each patient exhibited their own signature of endogenous pain encoding. The diversity of the individual cortical signatures of chronic pain encoding results bridge between clinical observations and neuroimaging; they add to the understanding of chronic pain as a complex and multifaceted disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.