Evidence map›Paper›PMID 34921324›Full record

ArticlePediatric cardiology2022

Circulatory Response to Rapid Volume Expansion and Cardiorespiratory Fitness in Fontan Circulation.

Thomas Möller, Vibeke Klungerbo, Simone Diab, Henrik Holmstrøm, Elisabeth Edvardsen, Guro Grindheim, Henrik Brun, Erik Thaulow, Alvaro Köhn-Luque, Assami Rösner and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thomas MöllerDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway. thomas.moller@ous-hf.no.ORCID http://orcid.org/0000-0002-1159-3206
Vibeke KlungerboDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway.
Simone DiabDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway.
Henrik HolmstrømDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway.
Elisabeth EdvardsenInstitute of Physical Performance, Norwegian School of Sport and Sciences, Oslo, Norway.
Guro GrindheimDivision of Emergencies and Critical Care, Oslo University Hospital - Rikshospitalet, Oslo, Norway.
Henrik BrunDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway.
Erik ThaulowDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway.
Alvaro Köhn-LuqueOslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway.
Assami RösnerDepartment of Cardiology, University Hospital of North Norway, Tromsø, Norway.
Gaute DøhlenDepartment of Paediatric Cardiology, Oslo University Hospital Rikshospitalet, Nydalen, P.O. Box 4950, 0424, Oslo, Norway.

Funding

ekstrastiftelsen helse og rehabilitering 11042helse sør-øst rhf 2014077
6 · The paper itself

Abstract

The role of dysfunction of the single ventricle in Fontan failure is incompletely understood. We aimed to evaluate hemodynamic responses to preload increase in Fontan circulation, to determine whether circulatory limitations in different locations identified by experimental preload increase are associated with cardiorespiratory fitness (CRF), and to assess the impact of left versus right ventricular morphology. In 38 consecutive patients (median age = 16.6 years, 16 females), heart catheterization was supplemented with a rapid 5-mL/kg body weight volume expansion. Central venous pressure (CVP), ventricular end-diastolic pressure (VEDP), and peak systolic pressure were averaged for 15‒30 s, 45‒120 s, and 4‒6 min (steady state), respectively. CRF was assessed by peak oxygen consumption (VO

Indexed as

Cardiorespiratory FitnessFontan ProcedureAdolescentAdultFemaleHumansRetrospective StudiesYoung AdultFontan circulationHemodynamicsPreload challengeTranspulmonary gradientUniventricular congenital heart defectsVentricular function

Identifiers

PMID34921324
PMCPMC9005395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.