ArticleCommunications biology2021
Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- DNA methylation aging and transcriptomic studies in horses.Nature communications · 2022Pooled it
- Imputation in the Wild: Genome-Wide Robustness and Fine-Scale Limitations of Low-Coverage Genomes in Endangered Species.Molecular ecology resources · 2026Article
- Epigenetic Age Estimation for Hawaiian False Killer Whales (Pseudorca crassidens) in the Absence of 'Known-Age' Individuals.Molecular ecology resources · 2026Article
- Fish species lifespan prediction from promoter cytosine-phosphate-guanine density.Molecular ecology resources · 2025Article
- CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.Genome biology · 2025Article
- Age is not just a number: How incorrect ageing impacts close-kin mark-recapture estimates of population size.Ecology and evolution · 2024Article
- Pan-primate studies of age and sex.GeroScience · 2023Article
- Epigenetic aging in cows is accelerated by milk production.Epigenetics · 2023Article
- Universal DNA methylation age across mammalian tissues.Nature aging · 2023Article
- DNA methylation networks underlying mammalian traits.Science (New York, N.Y.) · 2023Article
- Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023Review
- Multi-tissue DNA methylation aging clocks for sea lions, walruses and seals.Communications biology · 2023Article
- DNA methylation-based profiling of horse archaeological remains for age-at-death and castration.iScience · 2023Article
- Immunosenescence and inflammaging in the aged horse.Immunity & ageing : I & A · 2023Review
- Identifying epigenetic aging moderators using the epigenetic pacemaker.Frontiers in bioinformatics · 2023Article
- Unlocking Horse Y Chromosome Diversity.Genes · 2022Review
- DNA methylation profile in beef cattle is influenced by additive genetics and age.Scientific reports · 2022Article
- A mammalian methylation array for profiling methylation levels at conserved sequences.Nature communications · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective conservation and management of threatened wildlife populations require an accurate assessment of age structure to estimate demographic trends and population viability. Epigenetic aging models are promising developments because they estimate individual age with high accuracy, accurately predict age in related species, and do not require invasive sampling or intensive long-term studies. Using blood and biopsy samples from known age plains zebras (Equus quagga), we model epigenetic aging using two approaches: the epigenetic clock (EC) and the epigenetic pacemaker (EPM). The plains zebra EC has the potential for broad application within the genus Equus given that five of the seven extant wild species of the genus are threatened. We test the EC's ability to predict age in sister taxa, including two endangered species and the more distantly related domestic horse, demonstrating high accuracy in all cases. By comparing chronological and estimated age in plains zebras, we investigate age acceleration as a proxy of health status. An interaction between chronological age and inbreeding is associated with age acceleration estimated by the EPM, suggesting a cumulative effect of inbreeding on biological aging throughout life.
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