ArticleScientific reports2021
Human Achilles tendon mechanical behavior is more strongly related to collagen disorganization than advanced glycation end-products content.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02616263 (Muscle, Joint and Movement Deterioration Contributing to Neuropathic Forefoot Deformity), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle, Joint and Movement Deterioration Contributing to Neuropathic Forefoot Deformity
Who cites it
21 citing papers in PubMed, 20 citations in OpenAlex.
- Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review).International journal of molecular medicine · 2026Review
- Serum Advanced Glycation End Products as Drivers of Poor Tendon Outcomes in Diabetes? An Emerging Hypothesis and Narrative Review.Endocrinology, diabetes & metabolism · 2026Review
- Impact of controlled type 2 diabetes on muscle-tendon mechanics.Acta diabetologica · 2026Article
- Extracellular matrix microarchitecture modulates cellular behavior and extracellular vesicle phenotypes in biomimetic tendon models.Bioengineering & translational medicine · 2026Article
- The impact of type 2 diabetes on tendon material properties and locomotor function in the db/db mouse.Experimental physiology · 2026Article
- Clinical Outcomes of Injectable Porcine Collagen in Diabetic Patients with Achilles Tendinopathy: A Retrospective Study.Journal of clinical medicine · 2026Article
- Fatigue loading and volumetric microscopy demonstrate changes to the mouse cervix throughout and after pregnancy.Connective tissue research · 2025Article
- How Does Tendon Region, Donor, and the Presence of Disease Affect Protein Composition of the Achilles Tendon?Clinical orthopaedics and related research · 2025Article
- Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Erroneous Differentiation of Tendon Stem/Progenitor Cells in the Pathogenesis of Tendinopathy: Current Evidence and Future Perspectives.Stem cell reviews and reports · 2025Review
- Exploring the Intersection of Diabetes and Musculoskeletal Health : Diabetes and Musculoskeletal Health.Galen medical journal · 2025Review
- Advanced glycation end products impair the repair of injured tendon: a study in rats.BMC musculoskeletal disorders · 2024Article
- Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- The impact of diabetes mellitus on tendon pathology: a review.Frontiers in pharmacology · 2024Review
- Advanced-Glycation Endproducts: How cross-linking properties affect the collagen fibril behavior.Journal of the mechanical behavior of biomedical materials · 2023Article
- Quantative MRI predicts tendon mechanical behavior, collagen composition, and organization.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Sound touch elastography of Achilles tendons in patients with type 2 diabetes mellitus versus healthy adults.Diabetology & metabolic syndrome · 2023Article
- The influence of AGEs and enzymatic cross-links on the mechanical properties of collagen fibrils.Journal of the mechanical behavior of biomedical materials · 2023Article
- Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking.Journal of diabetes science and technology · 2023Article
- Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products.PloS one · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Diabetes is associated with impaired tendon homeostasis and subsequent tendon dysfunction, but the mechanisms underlying these associations is unclear. Advanced glycation end-products (AGEs) accumulate with diabetes and have been suggested to alter tendon function. In vivo imaging in humans has suggested collagen disorganization is more frequent in individuals with diabetes, which could also impair tendon mechanical function. The purpose of this study was to examine relationships between tendon tensile mechanics in human Achilles tendon with accumulation of advanced glycation end-products and collagen disorganization. Achilles tendon specimens (n = 16) were collected from individuals undergoing lower extremity amputation or from autopsy. Tendons were tensile tested with simultaneous quantitative polarized light imaging to assess collagen organization, after which AGEs content was assessed using a fluorescence assay. Moderate to strong relationships were observed between measures of collagen organization and tendon tensile mechanics (range of correlation coefficients: 0.570-0.727), whereas no statistically significant relationships were observed between AGEs content and mechanical parameters (range of correlation coefficients: 0.020-0.210). Results suggest that the relationship between AGEs content and tendon tensile mechanics may be masked by multifactorial collagen disorganization at larger length scales (i.e., the fascicle level).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.