Evidence map›Paper›PMID 34921156›Full record

ArticleScientific reports2021

Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review.

Camila A Picchio, Sabela Lens, Manuel Hernandez-Guerra, Juan Arenas, Raúl J Andrade, Javier Crespo, Javier García-Samaniego, Manuel Romero-Gómez, Juan Turnes, José Luis Calleja and 8 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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  7. Implementing a new HCV model of care for people who use drugs.JHEP reports : innovation in hepatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 1 country.

Camila A PicchioBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Sabela LensLiver Unit, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain.
Manuel Hernandez-GuerraDepartment of Gastroenterology, University Hospital of the Canary Islands, San Cristóbal de La Laguna, Spain.
Juan ArenasBiodonostia, Liver Diseases Research Group, Osakidetza Basque Health Service, Donostia University Hospital, San Sebastián, Spain.
Raúl J AndradeCIBER Hepatic and Digestive Diseases (CIBERehd), Instituto Carlos III, Madrid, Spain.
Javier CrespoGastroenterology and Hepatology Unit, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.
Javier García-SamaniegoCIBER Hepatic and Digestive Diseases (CIBERehd), Instituto Carlos III, Madrid, Spain.
Manuel Romero-GómezUCM Digestive Diseases, Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Universidad de Sevilla, Seville, Spain.
Juan TurnesComplejo Hospitalario Universitario de Pontevedra, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Pontevedra, Spain.
José Luis CallejaCIBER Hepatic and Digestive Diseases (CIBERehd), Instituto Carlos III, Madrid, Spain.
Miguel Ángel SimónDepartment of Digestive Diseases, Hospital Clínico de Zaragoza, Zaragoza, Spain.
Trenton M WhiteBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.
Mar Riveiro-BarcielaLiver Unit, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
Anna PocurullLiver Unit, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain.
Dalia Morales-ArraezDepartment of Gastroenterology, University Hospital of the Canary Islands, San Cristóbal de La Laguna, Spain.
Alexandra GómezBiodonostia, Liver Diseases Research Group, Osakidetza Basque Health Service, Donostia University Hospital, San Sebastián, Spain.
Maria Buti *CIBER Hepatic and Digestive Diseases (CIBERehd), Instituto Carlos III, Madrid, Spain.
Jeffrey V Lazarus *Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain. Jeffrey.Lazarus@isglobal.org.
Hospital Universitario de Canarias · ESInstituto de Salud Carlos III · ESUniversitat de Barcelona · ESVall d'Hebron Hospital Universitari · ESBarcelona Institute for Global Health · ESBiogipuzkoa Health Research Institute · ESCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESComplejo Hospitalario de Pontevedra · ESHospital Clínic de Barcelona · ESHospital Clínico Universitario Lozano Blesa · ESHospital Universitario Virgen del Rocío · ESOsakidetza · ESUniversidad de Cantabria · ESUniversidad de Málaga · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male (p < 0.001), being Spanish-born (p < 0.001), and having an unknown origin of referral (p = 0.08) were associated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patients and late-stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitis specialist care is frequent in Spain, despite being a country with unrestricted treatment access. Initiatives to reduce LP should specifically target men, older individuals, foreign-born populations for CHB, and Spanish nationals for CHC.

Indexed as

Hepatitis B, ChronicHepatitis C, ChronicHospitals, TeachingRegistriesAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSpain

Identifiers

PMID34921156
PMCPMC8683418
OpenAlexW4200618210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.