Trial reportScientific reports2021
Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- No evidence for the benefit of PPIs in the treatment of acute pancreatitis: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Usefulness of Random Forest Algorithm in Predicting Severe Acute Pancreatitis.Frontiers in cellular and infection microbiology · 2022Trial
- Article
- Dynamic Assessment of the C-Reactive Protein-to-Albumin Ratio Improves Early Prediction of Severe Acute Pancreatitis: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Creatinine-Derived Composite Indices for Improved Mortality Prediction in Dogs with Acute Pancreatitis.Animals : an open access journal from MDPI · 2026Article
- Machine learning model for early prediction of acute respiratory failure in acute pancreatitis: Multicenter validation.iScience · 2026Article
- Evaluation of the Admission Neutrophil Percentage-to-Albumin Ratio for Predicting the Severity of Acute Pancreatitis.Biomedicines · 2026Article
- Predictive accuracy of clinical, laboratory, and radiological scores for severe acute pancreatitis.Scientific reports · 2026Article
- Association between lactate-to-albumin ratio and 30-day all-cause mortality in patients with acute pancreatitis-associated acute kidney injury.Scientific reports · 2026Article
- Review
- Liver-pancreas communication in disease and drug development.Acta pharmaceutica Sinica. B · 2026Review
- Prognostic analysis of acute pancreatitis due to different etiologies and establishment and validation of an early prediction model.Lipids in health and disease · 2026Article
- Interpretable machine learning reveals phosphorus-to-albumin ratio as a novel predictor of mortality and acute kidney injury in critically ill pancreatitis patients: a multi-center retrospective analysis.European journal of medical research · 2026Article
- Prognostic value of inflammatory biochemical markers (IL-8, PCT, CRP) for cardiovascular disease in patients with pancreatitis.Journal of medical biochemistry · 2026Article
- Clinical utility of the lactate-to-albumin ratio for predicting mortality in elderly severe acute pancreatitis.Frontiers in medicine · 2026Article
- Chronic liver disease impacting the severity of acute pancreatitis: a detailed narrative review of the literature.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Association of albumin trajectories and cumulative exposure with in-hospital mortality in acute pancreatitis: a retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Blood urea nitrogen to albumin ratio as a robust predictor of in-hospital mortality in patients with predicted severe acute pancreatitis: a retrospective multicenter observational study.International journal of surgery (London, England) · 2026Observational
Corrections and comments
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Authors and funding
32 authors at 12 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the first 48 h (n = 1149) and anytime during hospitalization (n = 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (< 35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (< 25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276-98.908) and mortality (OR 16.83; CI 8.32-35.13). Albumin loss during AP was strongly associated with severity (p < 0.001) and mortality (p = 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.