ArticleNature communications2021
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 1 pooled it
15.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
207 citing papers in PubMed, 1 synthesis or guideline pooled it, 278 citations in OpenAlex.
- The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review.Journal of cancer research and clinical oncology · 2024Pooled it
- Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC.Oncoimmunology · 2026Article
- Single-cell and intercellular communication analyses reveal DLL3 as a key regulator in the glioma tumor microenvironment.Molecular therapy. Nucleic acids · 2026Article
- Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Article
- Tumoral and Systemic Immune Correlates of Response to Concurrent Pembrolizumab and Chemoradiotherapy in Patients with Resected High-Risk Head and Neck Squamous Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- CD55 organizes lipid raft-LCK signaling to potentiate NK-cell antitumor immunity.Cell research · 2026Article
- Identification of marginal zone B cells in head and neck cancer with immunomodulatory characteristics.Journal of advanced research · 2026Article
- Integrative single-cell and machine learning analysis identifies a tumor doubling time-related prognostic signature and therapeutic targets in head and neck squamous cell carcinoma.Translational oncology · 2026Article
- scMustree: a multi-scale functional hierarchy for single-cell transcriptomic analysis.Bioinformatics (Oxford, England) · 2026Article
- DSG2 Expression Marks a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma.Cancers · 2026Article
- Review
- ZC3H13-mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti-PD-1 response in HNSCC.Clinical and translational medicine · 2026Article
- Targeting TROP2 and Exploiting AUNIP as a Determinant of ADC Cytotoxicity and Chemosensitivity in HNSCC and ESCA Cancers.Molecular carcinogenesis · 2026Article
- Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Single-cell transcriptomics reveals glycolytic heterogeneity and identifies STC2 as a key regulator of metabolic reprogramming in osteosarcoma.Molecular and cellular biochemistry · 2026Article
- Development of a Clinical Assay to Guide Patient Therapy in HPV-Associated Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- A unified single-cell atlas of HNSCC: Toward characterizing HPV- and sex-associated TME variability.iScience · 2026Article
- Integrated Single-Cell and Spatial Analysis Reveals Context-Dependent Myeloid-T Cell Interactions in Response to Immune Checkpoint Blockade in Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
147 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 3 institutions in 2 countries.
Cornelius H L Kürten *Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-2720-0075
Aditi Kulkarni *UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Anthony R CilloUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3213-3129
Patricia M SantosUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Anna K RobleUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-9435-4939
Sayali OnkarUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Carly ReederUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Stephan LangDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Xueer ChenDeparment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Umamaheswar DuvvuriDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Seungwon KimDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Angen LiuDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Tracy TabibDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Robert LafyatisDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Jian FengUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Shou-Jiang GaoUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6194-1742
Tullia C BrunoUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6433-0207
Dario A A VignaliUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Xinghua LuDeparment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-8599-2269
Riyue BaoUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Lazar Vujanovic *UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1729-8619
Robert L FerrisUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. ferrisrl@upmc.edu.
University of Pittsburgh · USUniversity of Duisburg-Essen · DEUPMC Health System · US
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0MWILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2004 to 2026
$49.6MTraining in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2MMechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytesR01CA206517 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert L. Ferris, Lawrence P. Kane · 2016 to 2026
$4.6MInterpretable deep learning models for translational medicine RenewalR01LM012011 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tanner J. Freeman, XINGHUA LU · 2015 to 2026
$3.6MInhibition of lysosomal flux in carcinogen-induced head and neck cancerR01DE028343 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUVVURI, UMAMAHESWAR · 2019 to 2023
$1.9MNCI NIH HHS P30 CA047904NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA206517NCI NIH HHS T32 CA082084NIDCR NIH HHS R01 DE028343NLM NIH HHS R01 LM012011
Abstract
Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). To enable the development of more efficacious therapies, we aim to study the heterogeneity, signatures of unique cell populations, and cell-cell interactions of non-immune and immune cell populations in 6 human papillomavirus (HPV)
Indexed as
Cell CommunicationRNA-SeqSingle-Cell AnalysisAntigen-Presenting CellsB7-H1 AntigenCancer-Associated FibroblastsCD8-Positive T-LymphocytesEndothelial CellsEpithelial CellsGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansImmune Checkpoint ProteinsInflammationLigandsMacrophagesB7-H1 AntigenCD274 protein, humanImmune Checkpoint ProteinsLigands
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