Trial reportNature communications2021
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload-Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia.Molecular & cellular proteomics : MCP · 2026Article
- Red cell distribution width-to-albumin ratio predicts mortality in critically ill patients with gastrointestinal bleeding: A retrospective cohort study with external validation.The Journal of international medical research · 2026Article
- Deoxy-Piezo1 hyperactivity elevates pump-leak fluxes and lactate production in sickle cells.Biophysical journal · 2026Article
- Molecular and therapeutic frontiers in anemia therapy.The Journal of clinical investigation · 2026Review
- Methyltransferase complex subunit METTL3 maintains genome stability of erythroid cells via MTHFD1-mediated nucleotide biosynthesis.The Journal of clinical investigation · 2026Article
- In response to stress: quicker, yet bigger.Blood advances · 2026Article
- Epo and hypoxia accelerate a pattern of gradual cell cycle shortening in BFU-e and CFU-e erythroid progenitors in vivo.Blood advances · 2026Article
- CCND3 Suppression Ameliorates β-Thalassaemia in a Murine Disease Model: A Potential Therapeutic Strategy.Cells · 2026Article
- Orai1 acts as a novel CaExperimental & molecular medicine · 2026Article
- p27Kip1 regulates γ-globin production.Blood · 2026Article
- The Inflammatory Milieu Exacerbates Anemia of Chronic Kidney Disease: From the Gut-Kidney Axis to Bone Marrow Hematopoiesis Inhibition.Kidney & blood pressure research · 2026Review
- IL-17 stimulates erythropoiesis in vivo by amplifying the response of erythroid progenitors to erythropoietin.PLoS biology · 2025Article
- Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance.Channels (Austin, Tex.) · 2025Review
- Advances in the characterization of in vitro-generated red blood cells: from biophysical properties to functional applications.Stem cell research & therapy · 2025Review
- Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression.Blood advances · 2025Article
- Genomic signatures of subterranean lifestyle and ecological adaptation in Myospalax.BMC biology · 2025Article
- The oncogene protein kinase PIM1 regulates mammalian erythroblast enucleation.Communications biology · 2025Article
- C-COUNT: a convolutional neural network-based tool for automated scoring of erythroid colonies.Experimental hematology · 2025Article
- Advances and challenges in the treatment of myelodysplastic syndromes.Experimental hematology & oncology · 2025Review
- Hyperactive deoxy-PIEZO1 shapes the circulatory life cycle of irreversibly sickled cells.Biophysical journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Daniel Hidalgo *Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-2615-2868
Jacob Bejder *Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9698-9188
Ramona PopDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kyle GellatlyProgram in Bioinformatics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-3500-2025
Yung HwangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-0098-8963
S Maxwell ScalfDepartment of Cell Biology and Yale Stem Cell Center, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1145-0587
Anna E EastmanDepartment of Cell Biology and Yale Stem Cell Center, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-1455-291X
Jane-Jane ChenInstitute for Medical Engineering & Science, MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4372-6907
Lihua Julie ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-7416-0590
Jules A A C HeubergerCentre for Human Drug Research, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7202-5088
Shangqin GuoDepartment of Cell Biology and Yale Stem Cell Center, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1157-0423
Mark J KouryDepartment of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7303-7694
Nikolai Baastrup NordsborgDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. nbn@nexs.ku.dk.ORCID http://orcid.org/0000-0001-7077-9265
Merav SocolovskyDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. merav.socolovsky@umassmed.edu.ORCID http://orcid.org/0000-0001-6747-7960
University of Massachusetts Chan Medical School · USYale Cancer Center · USUniversity of Copenhagen · DKCentre for Human Drug Research · NLHarvard University · USVanderbilt University Medical Center · US
Funding
Novel Growth Factor Regulators of Early ErythropoieisisR01HL141402 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KLEIN, ALLON MOSHE, SOCOLOVSKY, MERAV · 2018 to 2021
$2.6MSpecialized cell cycles in early erythropoiesisR01DK120639 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SOCOLOVSKY, MERAV · 2019 to 2023
$2.2MHRI-eIF2a Phosphorylation Signaling in Oxidative Stress and ErythropoiesisR01DK087984 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHEN, JANE-JANE · 2010 to 2017
$2.1MEpigenetic and Cell Cycle Functions of Glucocorticoids in Erythropoietic StressR01DK100915 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SOCOLOVSKY, MERAV · 2014 to 2018
$1.8MEnhancing the success of underrepresented students in the biomedical sciencesR25GM113686 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAPANE, KATE L, LEWIS, BRIAN C · 2015 to 2019
$1.7MNHLBI NIH HHS R01 HL141402NIDDK NIH HHS R01 DK087984NIDDK NIH HHS R01 DK100915NIDDK NIH HHS R01 DK120639NIGMS NIH HHS R25 GM113686
Abstract
The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for erythroblast survival, but its other functions are not well characterized. Here we use Epor
Indexed as
Cell CycleCell SizeErythropoiesisAdultAnimalsAntigens, CDbcl-X ProteinCD4 AntigensCell DifferentiationCell NucleusCell SurvivalCyclin-Dependent Kinase Inhibitor p27Embryo, MammalianErythroblastsErythrocytesErythropoietinAntigens, CDbcl-X ProteinCD4 AntigensCD71 antigenCyclin-Dependent Kinase Inhibitor p27eIF2alpha kinase, mouseErythropoietinIronProtein Serine-Threonine KinasesReceptors, ErythropoietinReceptors, Transferrin
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.