Evidence map›Paper›PMID 34921108›Full record

ArticleNeurology2022

Association of Head Injury With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Cohort.

Andrea L C Schneider, Rebecca F Gottesman, Gregory L Krauss, James Gugger, Ramon Diaz-Arrastia, Anna Kucharska-Newton, Juebin Huang, Emily L Johnson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Associations Between Prior Head Injury, Physical Functioning, and Frailty in the Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea L C SchneiderFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson. andrea.schneider@pennmedicine.upenn.edu.ORCID 0000-0003-0026-5052
Rebecca F GottesmanFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.
Gregory L KraussFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.
James GuggerFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.ORCID 0000-0003-1113-2984
Ramon Diaz-ArrastiaFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.
Anna Kucharska-NewtonFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.
Juebin HuangFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.
Emily L JohnsonFrom the Department of Neurology (A.L.C.S., J.G., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Stroke Branch (R.F.G.), National Institutes of Neurological Disorders and Stroke Intramural Research Program, Bethesda; Department of Neurology (G.L.K., E.L.J.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology (A.K.-N.), University of North Carolina at Chapel Hill; Department of Epidemiology (A.K.-N.), University of Kentucky, Lexington; and Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson.
University of North Carolina at Chapel Hill · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
Late-onset Epilepsy and CognitionK23AG063899 · NIA · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, EMILY · 2020 to 2024
$973k
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's diseaseK24AG052573 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOTTESMAN, REBECCA F · 2016 to 2020
$803k
NHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K23 AG063899NIA NIH HHS K24 AG052573
6 · The paper itself

Abstract

BACKGROUND AND

objectivesLate-onset epilepsy (LOE; i.e., epilepsy starting in later adulthood) affects a significant number of individuals. Head injury is also a risk factor for acquired epilepsy, but the degree to which prior head injury may contribute to LOE is less well understood. Our objective was to determine the association between head injury and subsequent development of LOE.

methodsIncluded were 8,872 participants enrolled in the Atherosclerosis Risk in Communities (ARIC) study with continuous Centers for Medicare Services fee-for-service (FFS) coverage (55.1% women, 21.6% Black). We identified head injuries through 2018 from linked Medicare fee for service claims for inpatient/emergency department care, active surveillance of hospitalizations, and participant self-report. LOE cases through 2018 were identified from linked Medicare FFS claims. We used Cox proportional hazards models to evaluate associations of head injury with LOE, adjusting for demographic, cardiovascular, and lifestyle factors.

resultsThe adjusted hazard ratio (HR) for developing LOE after a history of head injury was 1.88 (95% confidence interval [CI] 1.44-2.43). There was evidence for dose-response associations with greater risk for LOE with increasing number of prior head injuries (HR 1.37, 95% CI 1.01-1.88 for 1 prior head injury and HR 3.55, 95% CI 2.51-5.02 for 2+ prior head injuries, compared to no head injuries) and with more severe head injury (HR 2.53, 95% CI 1.83-3.49 for mild injury and HR 4.90, 95% CI 3.15-7.64 for moderate/severe injury, compared to no head injuries). Associations with LOE were significant for head injuries sustained at older age (age ≥67 years: HR 4.01, 95% CI 2.91-5.54), but not for head injuries sustained at younger age (age < 67 years: HR 0.98, 95% CI 0.68-1.41). DISCUSSION: Head injury was associated with increased risk of developing LOE, particularly when head injuries were sustained at an older age, and there was evidence for higher risk for LOE after a greater number of prior head injuries and after more severe head injuries. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that an increased risk of late-onset epilepsy is associated with head injury and that this risk increases further with multiple and more severe head injuries.

Indexed as

AtherosclerosisCraniocerebral TraumaEpilepsyAdultAgedCohort StudiesFemaleHumansMaleMedicareRisk FactorsUnited States

Identifiers

PMID34921108
PMCPMC8883511
OpenAlexW4200279490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.