Evidence map›Paper›PMID 34921054›Full record

ReviewClinical medicine (London, England)2022

Indications and considerations for kidney biopsy: an overview of clinical considerations for the non-specialist.

Katherine L Hull, Sherna F Adenwalla, Peter Topham, Matthew P Graham-Brown

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05728216 (Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05728216 recruitingnot on this map

Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices

TypeobservationalSponsorCentre Hospitalier William Morey - Chalon sur SaôneRan2022 to 2028Enrolled50ConditionsAcute Kidney Injury, Chronic Kidney Diseases, Tomography, Optical CoherenceArmsDynamic full-field optical coherence tomography analysis of kidney biopsy
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Quantitative imaging in medicine and surgery · 2026
    Article
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  11. Review
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  15. Review
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  18. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  19. Article
  20. When is A Kidney Biopsy Indicated During the Treatment of Brain Cancer?European journal of case reports in internal medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine L HullUniversity Hospitals of Leicester NHS Trust, Leicester, UK and University of Leicester, Leicester, UK mgb23@leicester.ac.uk.
Sherna F AdenwallaUniversity Hospitals of Leicester NHS Trust, Leicester, UK and University of Leicester, Leicester, UK mgb23@leicester.ac.uk.
Peter TophamUniversity Hospitals of Leicester NHS Trust, Leicester, UK.
Matthew P Graham-BrownUniversity Hospitals of Leicester NHS Trust, Leicester, UK and University of Leicester, Leicester, UK mgb23@leicester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Around 3 million people in the UK have chronic kidney disease and 20% of hospital admissions are complicated by acute kidney injury. Decline in kidney function is not a diagnosis; it is essential to identify and treat underlying causes of acute and chronic kidney disease to either achieve recovery or slow the decline of kidney function. Thorough clinical assessment and simple investigations help determine the category of kidney injury (pre-renal, intrinsic or post-renal) and inform the need for kidney biopsy, which can provide significant information in the evaluation of suspected intrinsic kidney disease, supporting diagnosis, guiding prognosis and management, and identifying disease relapse. The procedure is invasive and not without risk, which although small has the potential to be both organ- and life-threatening. This review outlines roles of kidney biopsy for the non-specialist, with focus of its role in patients with diabetes, lupus, myeloma and in the older patient.

Indexed as

Acute Kidney InjuryRenal Insufficiency, ChronicBiopsyHumansKidneyPrognosisacute kidney injurychronic kidney diseasehaematuriakidney biopsyproteinuria

Identifiers

PMID34921054
PMCPMC8813013

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.