ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Saturating Nonlinearities of Contrast Response in Human Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Model-based estimation of the population contrast response function in human visual cortex.Journal of vision · 2026Article
- Modulation of Visual Contrast Perception Associated With Dorsal Attention Network Connectivity Assessed by Magnetoencephalography.Human brain mapping · 2026Article
- Covert spatial attention is uniform across cardinal meridians despite differential adaptation.Journal of vision · 2026Article
- Covert spatial attention is uniform across cardinal meridians despite differential adaptation.bioRxiv : the preprint server for biology · 2025Article
- Visual adaptation stronger at the horizontal than the vertical meridian: Linking performance with V1 cortical surface area.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Heterogeneous Effects of Cognitive Arousal on the Contrast Response in Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- How does orientation-tuned normalization spread across the visual field?Journal of neurophysiology · 2025Article
- Modeling neural contrast sensitivity functions in human visual cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Vagus nerve stimulation modulates information representation of sustained activity in layer specific manner in the rat auditory cortex.Frontiers in neural circuits · 2025Article
- Article
- Audiovisual interactions outside of visual awareness during motion adaptation.Neuroscience of consciousness · 2024Article
- What has vision science taught us about functional MRI?NeuroImage · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Response nonlinearities are ubiquitous throughout the brain, especially within sensory cortices where changes in stimulus intensity typically produce compressed responses. Although this relationship is well established in electrophysiological measurements, it remains controversial whether the same nonlinearities hold for population-based measurements obtained with human fMRI. We propose that these purported disparities are not contingent on measurement type and are instead largely dependent on the visual system state at the time of interrogation. We show that deploying a contrast adaptation paradigm permits reliable measurements of saturating sigmoidal contrast response functions (10 participants, 7 female). When not controlling the adaptation state, our results coincide with previous fMRI studies, yielding nonsaturating, largely linear contrast responses. These findings highlight the important role of adaptation in manifesting measurable nonlinear responses within human visual cortex, reconciling discrepancies reported in vision neuroscience, re-establishing the qualitative relationship between stimulus intensity and response across different neural measures and the concerted study of cortical gain control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.