SynthesisBMJ supportive & palliative care2022
Symptom clusters in patients receiving chemotherapy: A systematic review.
Synthesis in BMJ supportive & palliative care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07481903 (Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors), which is not on this map. Cited by 62 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors
Who cites it
62 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The Effectiveness of Interventions Based on Symptom Clusters for Symptom Burden and Quality of Life Among Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.Research in nursing & health · 2026Pooled it
- Online self-compassion-based interventions on patient outcomes in patients with cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Symptom clusters and their temporal patterns in breast cancer patients undergoing chemotherapy: a systematic review of cross-sectional and longitudinal studies.Frontiers in oncology · 2026Pooled it
- Symptom clusters in colorectal cancer: a systematic review of assessment tools, statistical methods, and symptom patterns.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach.JMIR cancer · 2025Pooled it
- Common patient-reported sources of cancer-related distress in adults with cancer: A systematic review.Cancer medicine · 2024Pooled it
- Symptom clusters and their impact on quality of life in multiple myeloma survivors: Secondary analysis of BMT CTN 0702 trial.British journal of haematology · 2024Trial
- Symptom-Heavy Nutritional Insecurity in Older Adults Initiating Chemotherapy.Healthcare (Basel, Switzerland) · 2026Article
- "Doing everything we can": parents' strategies for managing chemotherapy-related symptoms in children with leukemia at home.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Patient-reported symptom assessments and early chemotherapy discontinuation in routine gastrointestinal cancer care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Psychological Factors and Treatment Experiences Associated With Chemotherapy Side-Effect Expectations and Symptom Severity: A Prospective Longitudinal Study.Cancer medicine · 2026Article
- Exploring Core Symptoms and Symptom Clusters Among Older Adults with Hypertension-Diabetes Comorbidity: A Network Analysis.Healthcare (Basel, Switzerland) · 2026Article
- A mixed-method study of identifying symptom clusters in adult patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Latent profile analysis identifying symptom clusters of fatigue, sleep disturbance, pain, and anxiety and their associations with health-related quality of life and self-efficacy in patients undergoing peritoneal dialysis: a cross-sectional study.Health and quality of life outcomes · 2026Article
- Early chemotherapy symptom clusters predict quality of life and treatment adherence in lung cancer patients.Discover oncology · 2026Article
- Transdiagnostic Symptoms in Electronic Health Records of Sick-Listed Employees.Journal of occupational rehabilitation · 2026Article
- Symptom Burden and Treatment Satisfaction Among Patients with Cancer in a Day Care Unit.Medicina (Kaunas, Lithuania) · 2026Article
- Associations of personality profiles with stress and resilience characteristics among patients undergoing cancer chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Review
- A longitudinal analysis of symptom burden trajectories among breast cancer patients undergoing postoperative chemotherapy and related factors: a latent class growth model.Frontiers in public health · 2026Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
background and purposeSince 2001, symptom cluster research has grown considerably. However, because multiple methodological considerations remain, ongoing synthesis of the literature is needed to identify gaps in this area of symptom science. This systematic review evaluated the progress in symptom clusters research in adults receiving primary or adjuvant chemotherapy since 2016.
methodsEligible studies were published in English between 1 January 2017 and 17 May 2021; evaluated for and identified symptom clusters 'de novo;' and included only adults being treated with primary or adjuvant chemotherapy. Studies were excluded if patients had advanced cancer or were receiving palliative chemotherapy; symptoms were measured after treatment; symptom clusters were pre-specified or a patient-centred analytic approach was used. For each study, symptom instrument(s); statistical methods and symptom dimension(s) used to create the clusters; whether symptoms were allowed to load on more than one factor; method used to assess for stability of symptom clusters and associations with secondary outcomes and biomarkers were extracted.
resultsTwenty-three studies were included. Memorial Symptom Assessment Scale was the most common instrument and exploratory factor analysis was the most common statistical method used to identify symptom clusters. Psychological, gastrointestinal, and nutritional clusters were the most commonly identified clusters. Only the psychological cluster remained relatively stable over time. Only five studies evaluated for secondary outcomes. DISCUSSION: While symptom cluster research has evolved, clear criteria to evaluate the stability of symptom clusters and standardised nomenclature for naming clusters are needed. Additional research is needed to evaluate the biological mechanism(s) for symptom clusters. PROSPERO REGISTRATION NUMBER: CRD42021240216.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.