Evidence map›Paper›PMID 34920905›Full record

ReviewSeminars in diagnostic pathology2022

Histopathologic diagnosis of endometrial precancers: Updates and future directions.

Hao Chen, Amanda L Strickland, Diego H Castrillon

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in diagnostic pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Hao ChenDepartment of Pathology, Division of Gynecologic Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address: hao.chen@utsouthwestern.edu.
Amanda L StricklandDepartment of Pathology, Northwestern Feinberg School of Medicine, Chicago, IL, 60611, USA.
Diego H CastrillonDepartment of Pathology, Division of Gynecologic Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address: diego.castrillon@utsouthwestern.edu.
Northwestern University · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

Polymerase-mediated ultramutagenesis and carcinogenesis in miceR01CA237405 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CASTRILLON, DIEGO H · 2019 to 2023
$2.7M
NCI NIH HHS R01 CA237405
6 · The paper itself

Abstract

Early detection of endometrial cancer, especially its precancers, remains a critical and evolving issue in patient management and the quest to decrease mortality due to endometrial cancer. Due to many factors such as specimen fragmentation, the confounding influence of endogenous or exogenous hormones, and variable or overlapping histologic features, identification of bona fide endometrial precancers and their reliable discrimination from benign mimics remains one of the most challenging areas in diagnostic pathology. At the same time, the diagnosis of endometrial precancer, or the presence of suspicious but subdiagnostic features in an endometrial biopsy, can lead to long clinical follow-up with multiple patient visits and serial endometrial sampling, emphasizing the need for accurate diagnosis. Our understanding of endometrial precancers and their diagnosis has improved due to systematic investigations into morphologic criteria, the molecular genetics of endometrial cancer and their precursors, the validation of novel biomarkers and their use in panels, and more recent methods such digital image analysis. Although precancers for both endometrioid and non-endometrioid carcinomas will be reviewed, emphasis will be placed on the former. We review these advances and their relevance to the histopathologic diagnosis of endometrial precancers, and the recently updated 2020 World Health Organization (WHO) Classification of Female Genital Tumors.

Indexed as

Endometrial HyperplasiaEndometrial NeoplasmsPrecancerous ConditionsBiomarkersBiopsyFemaleHumansPTEN PhosphohydrolaseBiomarkersPTEN PhosphohydrolaseEndometrial atypical hyperplasia (AH)Endometrial cancerEndometrial precancerEndometrioid intraepithelial neoplasia (EIN)Pax2Ptenβ-catenin

Identifiers

PMID34920905
PMCPMC9035046
OpenAlexW4200117049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.