Evidence map›Paper›PMID 34920713›Full record

ArticleBMC urology2021

Denonvilliers' fascia acts as the fulcrum and hammock for continence after radical prostatectomy.

Xuwei Lu, Chang He, Sihong Zhang, Fan Yang, Zhuifeng Guo, Jiaqi Huang, Minke He, Jiawen Wu, Xia Sheng, Wenyao Lin and 3 more

Erratum issuedOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  4. Review
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  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Xuwei LuDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Chang HeDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Sihong ZhangDepartment of Urology, Zhongshan Hospital, Fudan University, Fenglin Rd 130, Shanghai, 200032, China.
Fan YangDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Zhuifeng GuoDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Jiaqi HuangDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Minke HeDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Jiawen WuDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Xia ShengDepartment of Pathology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Wenyao LinDepartment of Urology, Xuhui Hospital, Fudan University, Shanghai, 200031, China.
Jie ChengDepartment of Urology, Xuhui Hospital, Fudan University, Shanghai, 200031, China.
Jianming GuoDepartment of Urology, Zhongshan Hospital, Fudan University, Fenglin Rd 130, Shanghai, 200032, China. guo.jianming@zs-hospital.sh.cn.
Hang WangDepartment of Urology, Zhongshan Hospital, Fudan University, Fenglin Rd 130, Shanghai, 200032, China. wang.hang@zs-hospital.sh.cn.
Fudan University · CNMinhang District Central Hospital · CNZhongshan Hospital · CNObstetrics and Gynecology Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason.

methodsA multicenter cohort of 154 consecutive patients from 2018 to 2020, who was diagnosed with localized prostate cancer underwent either modified mini-incision retropubic radical prostatectomy (Mmi-RRP) or laparoscopic radical prostatectomy (LRP) or robotic-assisted radical prostatectomy (RARP). Seventy-two patients with Denonvilliers' fascia (DF) spared were included in DFS (Denonvilliers' fascia sparing) group. Whereas eighty-two patients with DF completely or partially dissected were set as Group Control. The primary outcome was immediate continence (ImC). Continuous data and categorical data were analyzed with t-test and Chi-square test, respectively. Odds ratios (ORs) were calculated with logistic regression.

resultsUrinary continence of Group DFS was significantly better than that of Group Control at each time point within one year after operation. Incidence rate of continence in Group DFS and Group Control were 83.3% vs 13.4% (P < 0.01) for ImC, 90.3% vs 30.5% (P < 0.01) at 3 months, 91.7% vs 64.6% (P < 0.01) at 6 months, and 93.1% vs 80.5% (P = 0.02) at 1 year after operation, respectively. Positive surgical margin (PSM) showed no significant difference (20.8% vs 20.7%, P = 1.0). In multivariate analysis, DFS showed importance for ImC post RP (OR = 26.4, P < 0.01).

conclusionsDenonvilliers' fascia acted as the fulcrum and hammock for continence post RP. Preservation of DF contributed to better continence after RP without increase of PSM. Trail registration Our research was conducted retrospectively and approved by the ethical committees of Minhang Hospital, but not registered.

Indexed as

FasciaAgedAged, 80 and overFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedProstateProstatectomyProstatic NeoplasmsRetrospective StudiesTransurethral Resection of ProstateUrinary IncontinenceDenonvilliers’ fasciaPositive surgical marginProstate cancerProstatectomyUrinary continence

Identifiers

PMID34920713
PMCPMC8680026
OpenAlexW4200041489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.