Evidence map›Paper›PMID 34920088›Full record

ArticleMetabolic engineering2022

Metabolic flux analysis of the non-transitory starch tradeoff for lipid production in mature tobacco leaves.

Kevin L Chu, Somnath Koley, Lauren M Jenkins, Sally R Bailey, Shrikaar Kambhampati, Kevin Foley, Jennifer J Arp, Stewart A Morley, Kirk J Czymmek, Philip D Bates and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Metabolic engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
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  4. Metabolic rewiring and biomass redistribution enable optimized mixotrophic growth in Chlamydomonas.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  12. Non-canonical plant metabolism.Nature plants · 2025
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  17. Efficient expression of a novelFrontiers in microbiology · 2025
    Article
  18. Review
  19. Unveiling the Secrets of Oil Palm Genetics: A Look into Omics Research.International journal of molecular sciences · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kevin L ChuDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Somnath KoleyDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Lauren M JenkinsDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Sally R BaileyDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA; United States Department of Agriculture-Agriculture Research Service, Donald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Shrikaar KambhampatiDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Kevin FoleyDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Jennifer J ArpDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Stewart A MorleyDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA; United States Department of Agriculture-Agriculture Research Service, Donald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Kirk J CzymmekDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA.
Philip D BatesInstitute of Biological Chemistry, Washington State University, Pullman, WA, 99164-6340, USA.
Doug K AllenDonald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA; United States Department of Agriculture-Agriculture Research Service, Donald Danforth Plant Science Center, St. Louis, Missouri, 63132, USA. Electronic address: doug.allen@ars.usda.gov.
Donald Danforth Plant Science Center · USUnited States Department of Agriculture · USWashington State University · US

Funding

Tools for Leveraging High-Resolution MS Detection of Stable Isotope Enrichments to Upgrade the Information Content of Metabolomics DatasetsU01CA235508 · NCI · VANDERBILT UNIVERSITY · PI ALLEN, DOUG, YOUNG, JAMEY D. · 2018 to 2021
$1.7M
NCI NIH HHS U01 CA235508
6 · The paper itself

Abstract

The metabolic plasticity of tobacco leaves has been demonstrated via the generation of transgenic plants that can accumulate over 30% dry weight as triacylglycerols. In investigating the changes in carbon partitioning in these high lipid-producing (HLP) leaves, foliar lipids accumulated stepwise over development. Interestingly, non-transient starch was observed to accumulate with plant age in WT but not HLP leaves, with a drop in foliar starch concurrent with an increase in lipid content. The metabolic carbon tradeoff between starch and lipid was studied using

Indexed as

Metabolic Flux AnalysisStarchNicotianaPlant LeavesPlants, Genetically ModifiedTriglyceridesStarchTriglycerides(13)C isotope LabelingAcyl-ACPsCarbon partitioningMetabolic flux analysisNicotiana tabacum (tobacco)Starch-triacylglycerol tradeoff

Identifiers

PMID34920088
PMCPMC8761171
OpenAlexW4200601975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.