Evidence map›Paper›PMID 34920047›Full record

ReviewInternational journal of cardiology2022

Diversity in modern heart failure trials: Where are we, and where are we going.

Uzoma Anaba, Abiodun Ishola, Alisha Alabre, Albert Bui, Marloe Prince, Henry Okafor, Onaopepo Kola-Kehinde, Joshua J Joseph, Darrion Mitchell, Bismarck C Odei and 4 more

Abstract readReview
In one paragraph

Review in International journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Artificial intelligence: Applications in cardio-oncology and potential impact on racial disparities.American heart journal plus : cardiology research and practice · 2024
    Article
  4. The Role of Social Support in Cardiovascular Clinical Trial Participation among Black Men: Black Impact.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Uzoma AnabaDivision of Cardiology, Ohio State University Medical Center, Columbus, OH, USA.
Abiodun IsholaDivision of Cardiology, Ohio State University Medical Center, Columbus, OH, USA; Division of Cardiology, St. Elizabeth Heart and Vascular Institute, Edgewood, KY, USA.
Alisha AlabreDivision of Cardiology, Ohio State University Medical Center, Columbus, OH, USA.
Albert BuiDepartment of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
Marloe PrinceDivision of Cardiology, Ochsner Medical Center, New Orleans, LA, USA.
Henry OkaforDivision of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Onaopepo Kola-KehindeDivision of Cardiology, Ohio State University Medical Center, Columbus, OH, USA.
Joshua J JosephDivision of Endocrinology, Diabetes and Metabolism, Ohio State University College of Medicine, USA.
Darrion MitchellDeparment of Radiation Oncology, Ohio State University Medical Center, Columbus, OH, USA.
Bismarck C OdeiDeparment of Radiation Oncology, Ohio State University Medical Center, Columbus, OH, USA.
Anezi UzenduDivision of Cardiology, Massachusetts General Hospital, Boston, MA, USA.
Karen Patricia WilliamsMartha S. Pitzer Center for Women, Children & Youth, College of Nursing, The Ohio State University, Columbus, OH, USA.
Quinn CapersDivision of Cardiology, Ohio State University Medical Center, Columbus, OH, USA.
Daniel AddisonDivision of Cardiology, Ohio State University Medical Center, Columbus, OH, USA. Electronic address: daniel.addison@osumc.edu.

Funding

CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAMT32HL110837 · NHLBI · UNIVERSITY OF MISSOURI KANSAS CITY · PI JOHN A SPERTUS · 2012 to 2026
$5.0M
The Role of The Renin-Angiotensin-Aldosterone System, ARMC5, and Neprilysin in Glucose Metabolism among African AmericansK23DK117041 · NIDDK · OHIO STATE UNIVERSITY · PI JOSEPH, JOSHUA J · 2018 to 2022
$1.0M
NHLBI NIH HHS T32 HL110837NIDDK NIH HHS K23 DK117041
6 · The paper itself

Abstract

Over the last three decades, increased attention has been given to the representation of historically underrepresented groups within the landscape of pivotal clinical trials. However, recent events (i.e., coronavirus pandemic) have laid bare the potential continuation of historic inequities in available clinical trials and studies aimed at the care of broad patient populations. Anecdotally, cardiovascular disease (CVD) has not been immune to these disparities. Within this review, we examine and discuss recent landmark CVD trials, with a specific focus on the representation of Blacks within several critically foundational heart failure clinical trials tied to contemporary treatment strategies and drug approvals. We also discuss solutions for inequities within the landscape of cardiovascular trials. Building a more diverse clinical trial workforce coupled with intentional efforts to increase clinical trial diversity will advance equity in cardiovascular care.

Indexed as

Cardiovascular DiseasesHeart FailureDrug ApprovalHumansBlackCardiovascular clinical trialsDisparities

Identifiers

PMID34920047
PMCPMC9023064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.