Evidence map›Paper›PMID 34919816›Full record

ArticleMolecular cell2021

PARP-1 drives slumber: A reciprocal relationship between sleep homeostasis and DNA damage repair.

Ueli Schibler

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Sleep deprivation induces genetic damage in mammalian cells: a systematic review.Revista da Associacao Medica Brasileira (1992) · 2024
    Pooled it
  2. Circadian clock and cancer.Military Medical Research · 2026
    Review
  3. The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging.International journal of molecular sciences · 2024
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ueli SchiblerDepartment of Molecular Biology, University of Geneva, CH-1211 Geneva-4, Switzerland. Electronic address: ueli.schibler@unige.ch.
University of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep-wake cycles are orchestrated by the circadian clock and a sleep homeostat that records accumulating sleep pressure. Zada et al. (2021) now show that DNA lesions, recognized by PARP-1, accumulate in neurons of zebrafish larvae and promote homeostatic sleep pressure.

Indexed as

Circadian RhythmPoly(ADP-ribose) Polymerase InhibitorsAnimalsDNA DamageHomeostasisSleepZebrafishPoly(ADP-ribose) Polymerase Inhibitors

Identifiers

PMID34919816
OpenAlexW4200417268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.