SynthesisNutrition reviews2022
A systematic review of adaptations and effectiveness of scaled-up nutrition interventions.
Synthesis in Nutrition reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- An Umbrella Review of Systematic Reviews of School-Based Nutrition Interventions to Determine Outcomes Used and Their Measurement Tools.Nutrition reviews · 2026Pooled it
- Assessing the scalability of healthy eating interventions within the early childhood education and care setting: secondary analysis of a Cochrane systematic review.Public health nutrition · 2023Pooled it
- Strategies for enhancing the implementation of school-based policies or practices targeting diet, physical activity, obesity, tobacco or alcohol use.The Cochrane database of systematic reviews · 2022Pooled it
- A theoretically designed scale-up intervention increases adoption of an effective school nutrition program 'SWAP IT': outcomes of a randomised trial.The international journal of behavioral nutrition and physical activity · 2026Trial
- Evaluation of a long day care intervention targeting the mealtime environment and curriculum to increase children's vegetable intake: a cluster randomised controlled trial using the multiphase optimisation strategy framework.Public health nutrition · 2024Trial
- Mapping intervention components from a randomized controlled trial to scale-up of an early life nutrition and movement intervention: The INFANT program.Frontiers in public health · 2022Trial
- Global Pathways to Thriving Children: Implementing Large-Scale Multicomponent Nutrition and Child Development Programs.The Journal of nutrition · 2026Article
- Do we consider scalability from the outset? A methodological review of pilot randomised controlled health trials.BMJ open · 2026Review
- Food systems and market pathways to childhood stunting in mining communities: evidence from a cross-sectional survey and a synthesis of context-responsive nutrition interventions.BMC public health · 2026Article
- Methodological considerations for evaluating scale-up programmes in healthcare: a methods review.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2026Review
- Reaching Priority Populations When Scaling Up: A Qualitative Study of Practitioners' Experiences of Implementing Early Childhood Health Interventions in Victoria, Australia.Maternal & child nutrition · 2025Article
- Scalability and scaling-up strategy of a physical activity policy intervention in Australian childcare centres.Health promotion international · 2025Article
- Characterisation of At-Scale Community Health Interventions Aimed to Improve Healthy Eating Behaviour in Australia: A Rapid Review.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025Review
- Understanding what drives schools to adopt effective school-based nutrition programs: a cross-sectional study of barriers and facilitators.Translational behavioral medicine · 2025Article
- Scaling up structured lifestyle interventions to improve the management of cardiometabolic diseases in low-income and middle-income countries: a systematic review of strategies, methods and outcomes.BMJ public health · 2025Article
- Assessing the scalability of health system interventions in Africa: protocol for a Delphi study.Health research policy and systems · 2024Article
- Learning health systems to implement chronic disease prevention programs: A novel framework and perspectives from an Australian health service.Learning health systems · 2024Article
- Process evaluation of an mHealth-based school education program to reduce salt intake scaling up in China (EduSaltS): a mixed methods study using the RE-AIM framework.BMC public health · 2024Article
- Research outcomes informing the selection of public health interventions and strategies to implement them: A cross-sectional survey of Australian policy-maker and practitioner preferences.Health research policy and systems · 2024Article
- Successful adaptation of an initiative to reduce unnecessary antibiotics for acute respiratory infections across two Veteran Affairs ambulatory healthcare systems.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPublic health nutrition interventions shown to be effective under optimal research conditions need to be scaled up and implemented in real-world settings.
objectivesThe primary aim for this review was to assess the effectiveness of scaled-up public health nutrition interventions with proven efficacy, as examined in a randomized controlled trial. Secondary objectives were to: 1) determine if the effect size of scaled-up interventions were comparable to the prescale effect, and; 2) identify any adaptations made during the scale-up process. DATA SOURCES: Six electronic databases were searched and field experts contacted. STUDY SELECTION: An intervention was considered scaled up if it was delivered on a larger scale than a preceding randomized controlled trial ("prescale") in which a significant intervention effect (P ≤ 0.05) was reported on a measure of nutrition. DATA EXTRACTION: Two reviewers independently performed screening and data extraction. Effect size differences between prescale and scaled-up interventions were quantified. Adaptations to scale-up studies were coded according to the Adaptome model.
resultsTen scaled-up nutrition interventions were identified. The effect size difference between prescale trials and scaled-up studies ranged from -32.2% to 222% (median, 50%). All studies made adaptations between prescale to scaled-up interventions.
conclusionThe effects of nutrition interventions implemented at scale typically were half that achieved in prior efficacy trials. Identifying effective scale-up strategies and methods to support retainment of the original prescale effect size is urgently needed to inform public health policy. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no.CRD42020149267.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.