ArticleMolecular biology and evolution2022
Ancient Demographics Determine the Effectiveness of Genetic Purging in Endangered Lizards.
Article in Molecular biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 64 citations in OpenAlex.
- Repeated genetic adaptation under demographic limits in kiwifruit.The Plant journal : for cell and molecular biology · 2026Article
- Homozygosity Accumulated Through Genetic Drift and Inbreeding Underpins High Mutation Load in an Endangered Beluga Whale Population.Molecular ecology · 2026Article
- Pangolin museum genomics reveal the dynamic genetic consequences and extinction risk of the critically endangered Chinese pangolin.Molecular biology and evolution · 2026Article
- The genome of the relict earless monitor lizard, Lanthanotus borneensis, and the Toxicofera hypothesis.BMC biology · 2026Article
- Large-scale genomic phylogeography provides insights into evolutionary history and conservation priorities of the white-bellied pangolin (Phataginus tricuspis).Molecular biology and evolution · 2026Article
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- Decoding the genome of Brainea insignis reveals insights into fern evolution and conservation.Nature communications · 2025Article
- Population genomic landscapes and insights for conservation of the critically endangered island-endemic Chinese pangolin in Taiwan.Science China. Life sciences · 2025Article
- Genomic insights into the evolutionary history and conservation of the living fossilPlant diversity · 2025Article
- Genomic and population genomic analyses reveal contrasting diversity and demographic histories in a critically endangered and a widespreadPlant diversity · 2025Article
- Dynamics of Deleterious Mutations and Purifying Selection in Small Population Isolates.Molecular biology and evolution · 2025Article
- Ecological Niche Adaptations Influence Transposable Element Dynamics in Pollinating and Non-Pollinating Fig Wasps.Ecology and evolution · 2025Article
- Genomic insights and the conservation potential of captive breeding: The case of Chinese alligator.Science advances · 2025Article
- High-resolution genome assembly and population genetic study of the endangered mapleHorticulture research · 2025Article
- Purging of Highly Deleterious Mutations Through an Extreme Bottleneck.Molecular biology and evolution · 2025Article
- Genomic consequences of intensive inbreeding in miniature inbred pigs.BMC genomics · 2025Article
- Runs of Homozygosity and Inferences in Wild Populations.Molecular ecology · 2025Review
- Enhancing inbreeding estimation and global conservation insights through chromosome-level assemblies of the Chinese and Malayan pangolin.GigaScience · 2025Article
- Article
- Outbreeding management offers the promise of genetic rescue for an endangered lizard.Current zoology · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The purging of deleterious alleles has been hypothesized to mitigate inbreeding depression, but its effectiveness in endangered species remains debatable. To understand how deleterious alleles are purged during population contractions, we analyzed genomes of the endangered Chinese crocodile lizard (Shinisaurus crocodilurus), which is the only surviving species of its family and currently isolated into small populations. Population genomic analyses revealed four genetically distinct conservation units and sharp declines in both effective population size and genetic diversity. By comparing the relative genetic load across populations and conducting genomic simulations, we discovered that seriously deleterious alleles were effectively purged during population contractions in this relict species, although inbreeding generally enhanced the genetic burden. However, despite with the initial purging, our simulations also predicted that seriously deleterious alleles will gradually accumulate under prolonged bottlenecking. Therefore, we emphasize the importance of maintaining a minimum population capacity and increasing the functional genetic diversity in conservation efforts to preserve populations of the crocodile lizard and other endangered species.
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