ArticleInflammatory bowel diseases2022
Composition and Stability of the Vaginal Microbiota of Pregnant Women With Inflammatory Bowel Disease.
Article in Inflammatory bowel diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Article
- Prevalence ofEpidemiology and infection · 2025Article
- Preliminary Characterization of Cervical Microflora in Pregnant Women with Cervical Incompetence.International journal of women's health · 2025Article
- Correlation analysis between changes in oral and vaginal/intestinal microbiota during pregnancy and threatened preterm birth in pregnant women.American journal of translational research · 2025Article
- Female reproductive tract-organ axes.Frontiers in immunology · 2023Review
- Comparison of vaginal microbiota between women with inflammatory bowel disease and healthy controls.PloS one · 2023Article
- A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances.Biologics : targets & therapy · 2022Review
- Cervical Cytological Findings and Vaginal Microbiota Alterations During Pregnancy: A Retrospective Analysis.Sage open pathologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease (IBD) is common in women of childbearing years, and active IBD during pregnancy is associated with increased rates of preterm delivery and low-birth-weight newborns. Changes in the vaginal microbiome have been associated with preterm delivery. We aimed to determine the taxonomic composition of the vaginal microbiota at 3 time points during pregnancy in a population of women with IBD.
methodsParticipants were recruited from the patient registry of the Preconception and Pregnancy IBD Clinic at Royal University Hospital in Saskatoon, Canada. Self-collected vaginal swabs were obtained from patients at each trimester. Microbiota profiles were created by cpn60 amplicon sequencing.
resultsWe characterized the vaginal microbiota of 32 pregnant participants with IBD (33 pregnancies) during each trimester. A total of 32 of 33 pregnancies resulted in a live birth with 43.8% (n = 14 of 32, 2 missing) by caesarean section; 2 of 32 were preterm. Microbiota compositions corresponded to previously described community state types, with most participants having microbiota dominated by Lactobacillus crispatus. In 25 of 29 participants in which samples were available for more than 1 time point, there was no change in the community state type over time. Prevalence of Mollicutes (Mycoplasma and/or Ureaplasma) was significantly higher in pregnant participants with IBD than in a previously profiled cohort of 172 pregnant women without IBD who delivered at term.
conclusionsThe vaginal microbiome of participants with IBD was stable throughout pregnancy. Prevalence of Mollicutes, which has been associated with preterm delivery, warrants further study in this patient group.
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