ArticleRheumatology (Oxford, England)2022
A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank.
Article in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.Human molecular genetics · 2025Pooled it
- Pooled it
- A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.Arthritis & rheumatology (Hoboken, N.J.) · 2023Pooled it
- The clinical utility of imaging in osteoarthritis and its importance in future prediction of total hip replacement; a nested case-control study within the AGES-Reykjavik cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Artificial intelligence enabled prediction of hip fragility fracture risk using hip radiograph: an attractive approach yet more work needs to be done.Skeletal radiology · 2026Article
- Progress in machine learning-assisted medical imaging for osteoarthritis and osteoporosis diagnosis: a narrative review.Quantitative imaging in medicine and surgery · 2026Review
- DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individuals.medRxiv : the preprint server for health sciences · 2026Article
- Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study.RMD open · 2026Article
- Analysis of leg bone lengths from whole-body dual-energy X-ray absorptiometry in the UK biobank.BJR artificial intelligence · 2026Article
- Identification of novel vertebral development factors through UK Biobank candidate gene search and body imaging analysis.Communications biology · 2025Article
- Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.Osteoarthritis and cartilage · 2025Article
- A novel classifier of radiographic knee osteoarthritis for use on knee DXA images is predictive of joint replacement in UK Biobank.Rheumatology advances in practice · 2025Article
- Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank.Osteoarthritis and cartilage open · 2024Article
- Three-Dimensional Reconstruction of Computed Tomography Imaging Is Not Reliable in Assessing Acetabular Rim Osteophytes or Acetabular Rim Pathology in Patients With Femoroacetabular Impingement.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis.Frontiers in endocrinology · 2024Review
- A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2023Article
- Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: Findings from a cross-sectional study in UK Biobank.Osteoarthritis and cartilage · 2023Article
- Big data, big consortia, and pain: UK Biobank, PAINSTORM, and DOLORisk.Pain reports · 2023Article
- Deep learning based phenotyping of medical images improves power for gene discovery of complex disease.NPJ digital medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveConventional scoring methods for radiographic hip OA (rHOA) are subjective and show inconsistent relationships with clinical outcomes. To provide a more objective rHOA scoring method, we aimed to develop a semi-automated classifier based on DXA images and confirm its relationships with clinical outcomes.
methodsHip DXAs in UK Biobank (UKB) were marked up for osteophyte area from which acetabular, superior and inferior femoral head osteophyte grades were derived. Joint space narrowing (JSN) grade was obtained automatically from minimum joint space width (mJSW) measures. Clinical outcomes related to rHOA comprised hip pain, hospital diagnosed OA (HES OA) and total hip replacement. Logistic regression and Cox proportional hazard modelling were used to examine associations between overall rHOA grade (0-4; derived from combining osteophyte and JSN grades) and the clinical outcomes.
resultsA toal of 40 340 individuals were included in the study (mean age 63.7), of whom 81.2% had no evidence of rHOA, while 18.8% had grade ≥1 rHOA. Grade ≥1 osteophytes at each location and JSN were associated with hip pain, HES OA and total hip replacement. Associations with all three clinical outcomes increased progressively according to rHOA grade, with grade 4 rHOA and total hip replacement showing the strongest association [57.70 (38.08-87.44)].
conclusionsOur novel semi-automated tool provides a useful means for classifying rHOA on hip DXAs, given its strong and progressive relationships with clinical outcomes. These findings suggest DXA scanning can be used to classify rHOA in large DXA-based cohort studies supporting further research, with the future potential for population-based screening.
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