Evidence map›Paper›PMID 34919641›Full record

ArticleBioscience, biotechnology, and biochemistry2022

The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.

Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Mohammad Shaokat Ali, Eriko Kage-Nakadai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience, biotechnology, and biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ayano TsuruGraduate School of Human Life Science, Osaka City University, Osaka 558-8585, Japan.
Yumi HamazakiGraduate School of Human Life Science, Osaka City University, Osaka 558-8585, Japan.
Shuta TomidaCenter for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Mohammad Shaokat AliGraduate School of Human Life Science, Osaka City University, Osaka 558-8585, Japan.
Eriko Kage-NakadaiGraduate School of Human Life Science, Osaka City University, Osaka 558-8585, Japan.ORCID 0000-0001-5068-0460
Osaka City University · JPOkayama University Hospital · JP

Funding

NIH HHS
6 · The paper itself

Abstract

Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans Proteinsp38 Mitogen-Activated Protein KinasesAnimalsMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 14MutationPropionibacteriaceaeReceptors, G-Protein-CoupledSignal TransductionCaenorhabditis elegans ProteinsMitogen-Activated Protein Kinase 14p38 Mitogen-Activated Protein KinasesReceptors, G-Protein-Coupledtir-1 protein, C elegansantimicrobial moleculeCaenorhabditis elegansCutibacterium acnesp38 MAPKtir-1

Identifiers

PMID34919641
PMCPMC8866249
OpenAlexW4200494082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.