Evidence map›Paper›PMID 34919559›Full record

ArticlePloS one2021

Equivalence of the GeneXpert System and GeneXpert Omni System for tuberculosis and rifampicin resistance detection.

Sophia B Georghiou, Riccardo Alagna, Daniela M Cirillo, Sergio Carmona, Morten Ruhwald, Samuel G Schumacher

Abstract readValidation Study
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Advances in TB testing.Advances in clinical chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophia B GeorghiouFIND, The Global Alliance for Diagnostics, Geneva, Switzerland.
Riccardo AlagnaIRCCS San Raffaele Scientific Institute, Milan, Italy.
Daniela M CirilloIRCCS San Raffaele Scientific Institute, Milan, Italy.
Sergio CarmonaFIND, The Global Alliance for Diagnostics, Geneva, Switzerland.
Morten RuhwaldFIND, The Global Alliance for Diagnostics, Geneva, Switzerland.ORCID 0000-0002-1597-441X
Samuel G SchumacherFIND, The Global Alliance for Diagnostics, Geneva, Switzerland.ORCID 0000-0002-6136-206X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A laboratory validation study was conducted to assess the equivalence of Xpert MTB/RIF Ultra testing on the GeneXpert System and the GeneXpert Omni System ('Omni') for tuberculosis and rifampicin resistance. High concordance of the two devices was demonstrated for well-characterized clinical samples as well as control materials, with controls tested on Omni at normal and challenging environmental conditions (i.e. 35°C, 90% relative humidity). Equivalence of the Cts for all probes was also shown. Equivalence was demonstrated for the Omni and GeneXpert devices for tuberculosis and rifampicin resistance detection for a diverse range of clinical specimens and environmental conditions.

Indexed as

Point-of-Care TestingAntibiotics, AntitubercularBacterial ProteinsDNA-Directed RNA PolymerasesDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsMycobacterium tuberculosisRifampinSputumTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryAntibiotics, AntitubercularBacterial ProteinsDNA-Directed RNA PolymerasesRifampinrpoB protein, Mycobacterium tuberculosis

Identifiers

PMID34919559
PMCPMC8682871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.