Evidence map›Paper›PMID 34919435›Full record

ArticleScience advances2021

A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia.

Oscar A Campos, Narsis Attar, Chen Cheng, Maria Vogelauer, Nathan V Mallipeddi, Stefan Schmollinger, Nedas Matulionis, Heather R Christofk, Sabeeha S Merchant, Siavash K Kurdistani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Histone acetylases are required for iron homeostasis in yeast.Acta biochimica et biophysica Sinica · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. GlialProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oscar A CamposDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5645-7275
Narsis AttarDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5847-7587
Chen ChengDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Maria VogelauerDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1360-0526
Nathan V MallipeddiDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2193-5932
Stefan SchmollingerQB3-Berkeley, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-7487-8014
Nedas MatulionisDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-7624-3090
Heather R ChristofkDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-8662-4425
Sabeeha S MerchantQB3-Berkeley, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-2594-509X
Siavash K KurdistaniDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-3295-3511

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Nutritional Cu Signaling and HomeostasisR01GM042143 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SABEEHA MERCHANT · 1995 to 2026
$4.6M
Nutrient Regulation of Cancer Cell GrowthR01CA215185 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Heather Christofk · 2018 to 2026
$4.3M
Nutritional Copper Signaling and HomeostasisR37GM042143 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MERCHANT, SABEEHA · 2011 to 2020
$4.3M
Understanding the function of histone H3 as an oxidoreductase enzymeR01GM140106 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURDISTANI, SIAVASH · 2021 to 2024
$1.8M
Dynamics of Global Histone Acetylation in Regulating Intracellular pHF30CA186619 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ATTAR, NARSIS · 2014 to 2016
$121k
NCI NIH HHS F30 CA186619NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA215185NIGMS NIH HHS R01 GM042143NIGMS NIH HHS R01 GM140106NIGMS NIH HHS R37 GM042143NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Disruptions to iron-sulfur (Fe-S) clusters, essential cofactors for a broad range of proteins, cause widespread cellular defects resulting in human disease. A source of damage to Fe-S clusters is cuprous (Cu

Identifiers

PMID34919435
PMCPMC8682991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.