Evidence map›Paper›PMID 34919348›Full record

ArticleCurrent protocols2021

Assembly of Multiple Full-Size Genes or Genomic DNA Fragments on Human Artificial Chromosomes Using the Iterative Integration System.

Nicholas C O Lee, Nikolai S Petrov, Vladimir Larionov, Natalay Kouprina

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicholas C O LeeDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Nikolai S PetrovDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Vladimir LarionovDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Natalay KouprinaDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · US

Funding

Study of hereditary prostate cancer and human artificial chromosomesZIABC010413 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LARIONOV, VLADIMIR · 2009 to 2025
$31.5M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC010413NCI NIH HHSNIH
6 · The paper itself

Abstract

Human artificial chromosomes (HACs) are gene delivery vectors that have been used for decades for gene functional studies. HACs have several advantages over viral-based gene transfer systems, including stable episomal maintenance in a single copy in the cell and the ability to carry up to megabase-sized genomic DNA segments. We have previously developed the alphoid

Indexed as

Chromosomes, Artificial, HumanAnimalsCHO CellsCricetinaeCricetulusDNAGenomicsHumansIn Situ Hybridization, FluorescenceDNADNA assemblygene deliveryHAChuman artificial chromosomeIISiterative integration system

Identifiers

PMID34919348
PMCPMC8730363
OpenAlexW4200479377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.