Evidence map›Paper›PMID 34919118›Full record

ArticleGenetics and molecular biology2021

The expression of LRRN4 was correlated with the progression and prognosis of colon adenocarcinoma (COAD) patients.

Yuxian Zhang, Jianlan Xie, Diangang Liu, Shengtao Zhu, Shutian Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yuxian ZhangBeijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Digestive Disease Center, National Clinical Research Center for Digestive Disease, Capital Medical University, Beijing Friendship Hospital, Department of Gastroenterology, Beijing, P. R. China.
Jianlan XieCapital Medical University, Beijing Friendship Hospital, Department of Pathology, Beijing, P.R. China.
Diangang LiuXuanwu Hospital, Capital Medical University, Department of General Surgery, Beijing, P. R. China.
Shengtao ZhuBeijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Digestive Disease Center, National Clinical Research Center for Digestive Disease, Capital Medical University, Beijing Friendship Hospital, Department of Gastroenterology, Beijing, P. R. China.
Shutian ZhangBeijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Digestive Disease Center, National Clinical Research Center for Digestive Disease, Capital Medical University, Beijing Friendship Hospital, Department of Gastroenterology, Beijing, P. R. China.ORCID http://orcid.org/0000-0003-2356-4397
Beijing Friendship Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our present study aims to investigate the value of LRRN4 in the progression and prognosis of COAD patients. All COAD and adjacent sample data was downloaded from TCGA database. Survival analysis was performed according to Kaplan-Meier method. The real-time quantitative PCR and immunohistochemistry analysis were conducted for validation in cell lines and tissues. The GSEA was conducted to find functional KEGG pathways. Multivariate Cox regression proportional hazard mode was used to determine whether LRRN4 expression was an independent prognostic factor. The LRRN4 expression in COAD samples were significantly higher than that in adjacent samples, which was consistent with our experiments in cell lines and tissues. Along with the increase of TNM Stage, LRRN4 expression had an increasing tendency. The COAD patients with high LRRN4 expression showed undesirable prognoses. Additionally, the TGF-β signaling pathway, WNT signaling pathway and other 25 pathways were significantly activated in the high LRRN4 expression group. In conclusion, high LRRN4 expression was closely related to the onset of COAD and it was a poor prognostic factor for COAD patients.

Identifiers

PMID34919118
PMCPMC8679243
OpenAlexW4200217790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.