Evidence map›Paper›PMID 34918394›Full record

ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2022

Fetal lipidome and incident risk of food allergy: A prospective birth cohort study.

Xiumei Hong, Liming Liang, Hongkai Ji, Pamela Frischmeyer-Guerrerio, Guoying Wang, Colleen Pearson, Meir Stampfer, Frank B Hu, Xiaobin Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Multi-omics profiling approach in food allergy.The World Allergy Organization journal · 2023
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-3992-1918
Liming LiangDepartments of Epidemiology and Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Pamela Frischmeyer-GuerrerioLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Colleen PearsonDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
Meir StampferDepartments of Epidemiology and Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Frank B HuDepartments of Epidemiology and Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Johns Hopkins University · USBrigham and Women's Hospital · USBoston University · USHarvard University · USNational Institute of Allergy and Infectious Diseases · US

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Pathogenesis of Food AllergyZIAAI001202 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FRISCHMEYER-GUERRERIO, PAMELA · 2015 to 2025
$10.2M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Inter-generational Link of Cardio-Metabolic Risk: Integrate Multi-OMICs with Birth CohortR01HD098232 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LIANG, LIMING, WANG, XIAOBIN · 2019 to 2022
$2.7M
Post Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3M
Maternal Exposure to Low Level Mercury, Metabolome, and Child Cardiometabolic Risk in Multi-Ethnic Prospective Birth CohortsR01ES031272 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, GUOYING, WANG, XIAOBIN · 2020 to 2024
$1.2M
Maternal and Cord Blood Metabolome, Infant Feeding, and Development of Food Allergy in a Prospective Birth CohortR21AI154233 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HONG, XIUMEI · 2020 to 2021
$450k
Establishing Precursors of Food Allergy in NewbornsR21AI079872 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2008 to 2009
$447k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases U01AI090727NIAID NIH HHS R21 AI079872NIAID NIH HHS R21 AI154233NIAID NIH HHS U01 AI090727NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R01 HD098232NIEHS NIH HHS R01 ES031272
6 · The paper itself

Abstract

backgroundLipids are proposed to be important in developing adaptive immunity and allergy. However, studies to date reported inconsistent findings.

objectiveTo examine newborn lipidome (a comprehensive profiling of circulating lipid metabolites) on child's risk of developing food allergy (FA). The maternal-cord joint effects of lipid metabolites on FA development were also investigated.

methodsThis study included 647 mother-child pairs from the Boston Birth Cohort and analyzed 202 lipid metabolites in cord plasma profiled by liquid chromatography tandem mass spectrometry. FA was defined based on standard clinical criteria. Logistic regression was applied to examine the relationships between individual metabolites and risk of FA.

resultsOf the 647 children, 61 developed FA. Cord triacylglycerols of long carbon chains and multiple double bonds were significantly associated with decreased risk of FA. These associations were comparable across strata of pertinent maternal and child covariates, and were independent of maternal triacylglycerols when assessed simultaneously. Besides, cord and maternal triacylglycerols had an additive effect in association with risk of FA: Children having high (≥Median) C56:8 triacylglycerol levels in both cord and maternal plasma were at the lowest risk of developing FA (OR = 0.24, 95% CI = 0.10-0.56, p = .001), compared to those having low levels in both cord and maternal plasma.

conclusionThis is the first birth cohort study to link altered cord plasma lipidome with future risk of development FA during childhood. It calls for further investigation on triacylglycerols of long carbon chains and multiple double bonds as potential novel predictive biomarkers and therapeutic targets for FA.

Indexed as

Food HypersensitivityLipidomicsBirth CohortCohort StudiesFemaleHumansInfant, NewbornProspective Studiesfood allergyfood sensitizationlipidomemother-child pairstriacylglycerol

Identifiers

PMID34918394
PMCPMC8881306
OpenAlexW4200412649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.