Evidence map›Paper›PMID 34918374›Full record

ArticleThe EMBO journal2022

Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner.

Md Murad Khan, Seowon Lee, Sergio Couoh-Cardel, Rebecca A Oot, Hyunmin Kim, Stephan Wilkens, Soung-Hun Roh

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. ATG16L1 controls mammalian vacuolar proton ATPase.The Journal of cell biology · 2025
    Article
  8. Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Interaction of yeast V-ATPase with TLDc protein Rtc5p.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Md Murad Khan *Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-7371-2995
Seowon Lee *School of Biological Science, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.ORCID 0000-0002-1539-8651
Sergio Couoh-Cardel *Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-5186-4648
Rebecca A OotDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-4680-8932
Hyunmin KimSchool of Biological Science, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.
Stephan WilkensDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-2721-2789
Soung-Hun RohSchool of Biological Science, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.ORCID 0000-0003-3851-7200
SUNY Upstate Medical University · USSeoul National University · KR

Funding

3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1M
Unified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6M
STRUCTURE OF THE VACUOLAR ATPASE BY ELECTRON MICROSCOPYR01GM058600 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 1999 to 2020
$4.8M
Structure and Regulatory Mechanisms of the Vacuolar ATPaseR35GM141908 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2021 to 2025
$2.1M
Acquisition of a 300 kV Electron Microscope for Structural BiologyS10OD021600 · OD · STANFORD UNIVERSITY · PI CHIU, WAH · 2016 to 2016
$2.0M
A novel tool for organelle and isoform specific targeting of V-ATPase in cancerR21CA228340 · NCI · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2019 to 2020
$388k
NCI NIH HHS R21 CA228340NIGMS NIH HHS P41 GM103832NIGMS NIH HHS R01 GM058600NIGMS NIH HHS R01 GM079429NIGMS NIH HHS R35 GM141908NIH HHS S10 OD021600
6 · The paper itself

Abstract

The vacuolar ATPase (V-ATPase) is a rotary motor proton pump that is regulated by an assembly equilibrium between active holoenzyme and autoinhibited V

Indexed as

Oxidative StressBinding SitesCryoelectron MicroscopyHoloenzymesMitochondrial ProteinsMutagenesisProtein BindingProtein MultimerizationSaccharomyces cerevisiae ProteinsVacuolar Proton-Translocating ATPasesHoloenzymesMitochondrial ProteinsOxr1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsVacuolar Proton-Translocating ATPasesVph1 protein, S cerevisiaeCryo-electron microscopyOxr1preversible disassemblyTLDc domainvacuolar ATPase

Identifiers

PMID34918374
PMCPMC8804929
OpenAlexW4200057279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.