Evidence map›Paper›PMID 34918246›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2022

Adjuvants: Engineering Protective Immune Responses in Human and Veterinary Vaccines.

Bassel Akache, Felicity C Stark, Gerard Agbayani, Tyler M Renner, Michael J McCluskie

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Introduction to the Immune System.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  3. Review
  4. Nanovaccines empowering CD8Theranostics · 2025
    Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bassel AkacheHuman Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada.
Felicity C StarkHuman Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada.
Gerard AgbayaniHuman Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada.
Tyler M RennerHuman Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada.
Michael J McCluskieHuman Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada. michael.mccluskie@nrc-cnrc.gc.ca.
National Research Council Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adjuvants are key components of many vaccines, used to enhance the level and breadth of the immune response to a target antigen, thereby enhancing protection from the associated disease. In recent years, advances in our understanding of the innate and adaptive immune systems have allowed for the development of a number of novel adjuvants with differing mechanisms of action. Herein, we review adjuvants currently approved for human and veterinary use, describing their use and proposed mechanisms of action. In addition, we will discuss additional promising adjuvants currently undergoing preclinical and/or clinical testing.

Indexed as

VaccinesAdjuvants, ImmunologicAdjuvants, PharmaceuticAntigensHumansImmunity, InnateAdjuvants, ImmunologicAdjuvants, PharmaceuticAntigensVaccinesAdjuvantHumanImmunomodulatoryVaccineVeterinary

Identifiers

PMID34918246
OpenAlexW4200471645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.