Evidence map›Paper›PMID 34918075›Full record

ArticleThe international journal of neuropsychopharmacology2022

Towards Modeling Anhedonia and Its Treatment in Zebrafish.

Murilo S de Abreu, Fabiano Costa, Ana C V V Giacomini, Konstantin A Demin, Konstantin N Zabegalov, Gleb O Maslov, Yuriy M Kositsyn, Elena V Petersen, Tatiana Strekalova, Denis B Rosemberg and 1 more

Open access · goldAbstract read
In one paragraph

Article in The international journal of neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Teleosts as behaviour test models for social stress.Frontiers in behavioral neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Murilo S de AbreuSchool of Pharmacy, Southwest University, Chongqing, China.ORCID 0000-0001-5562-0715
Fabiano CostaGraduate Program in Biological Sciences: Toxicological Biochemistry, Natural and Exact Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Ana C V V GiacominiBioscience Institute, University of Passo Fundo, Passo Fundo, RS, Brazil.
Konstantin A DeminDrug Screening Platform, School of Pharmacy, Southwest University, Chongqing, China.
Konstantin N ZabegalovNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Gleb O MaslovUral Federal University, Ekaterinburg, Russia.
Yuriy M KositsynNeurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Elena V PetersenLaboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
Tatiana StrekalovaDepartment of Preventive Medicine, Maastricht Medical Center Annadal, Maastricht, Netherlands.
Denis B RosembergGraduate Program in Biological Sciences: Toxicological Biochemistry, Natural and Exact Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Allan V KalueffSchool of Pharmacy, Southwest University, Chongqing, China.
Ural Federal University · RUSirius University of Science and Technology · RUUniversidade Federal de Santa Maria · BRMoscow Institute of Physics and Technology · RUSechenov University · RUSouthwest University · CNUniversidade de Passo Fundo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.

Indexed as

AnhedoniaZebrafishAnimalsAntidepressive AgentsBehavior, AnimalDisease Models, AnimalAntidepressive AgentsAnhedoniaanimal modelsantidepressantbehaviorzebrafish

Identifiers

PMID34918075
PMCPMC9017771
OpenAlexW4200192529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.