Evidence map›Paper›PMID 34918026›Full record

SynthesisThe American journal of clinical nutrition2022

PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).

Rachel A Murphy, Nathan Tintle, William S Harris, Maryam Darvishian, Matti Marklund, Jyrki K Virtanen, Sari Hantunen, Vanessa D de Mello, Jaakko Tuomilehto, Jaana Lindström and 22 more

Erratum issuedAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Docosahexaenoic Acid and Sleep Quality in Very and Extreme Preterm Infants.International journal of environmental research and public health · 2024
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Rachel A MurphyCancer Control Research, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0003-4383-5641
Nathan TintleDepartment of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.
William S HarrisFatty Acid Research Institute, Sioux Falls, SD, USA.ORCID 0000-0003-3042-9353
Maryam DarvishianCancer Control Research, BC Cancer, Vancouver, BC, Canada.
Matti MarklundThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Sari HantunenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Vanessa D de MelloInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jaakko TuomilehtoPublic Health, University of Helsinki, Helsinki, Finland.
Jaana LindströmFinnish Institute for Health and Welfare, Helsinki, Finland.
Matthew A BoltDepartment of Mathematics and Statistics, Dordt College, Sioux Center, IA, USA.
Ingeborg A BrouwerDepartment of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Alexis C WoodUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Mackenzie SennUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Susan RedlineDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Vilmundur GudnasonIcelandic Heart Association Research Institute, Kópavogur, Iceland.
Gudny EiriksdottirIcelandic Heart Association Research Institute, Kópavogur, Iceland.ORCID 0000-0002-8197-0652
Eva LindbergDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Sweden.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Buyun LiuDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Mercedes CarnethonDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Matti UusitupaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Luc DjousseDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ulf RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala, Sweden.
Lars LindDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala, Sweden.ORCID 0000-0003-2335-8542
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-5674-6341
Peilin ShiFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
David SiscovickNew York Academy of Medicine, New York, NY, USA.
Rozenn N LemaitreDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Dariush MozaffarianFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.ORCID 0000-0001-7958-9492

Funding

Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
NHLBI NIH HHS R35 HL135818
6 · The paper itself

Abstract

backgroundn-3 and n-6 PUFAs have physiologic roles in sleep processes, but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters.

objectivesWe sought to assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling sleeping in the Fatty Acids and Outcome Research Consortium.

methodsHarmonized, de novo, individual-level analyses were performed and pooled across 12 cohorts. Participants were 35-96 y old and from 5 nations. Circulating measures included α-linolenic acid (ALA), EPA, docosapentaenoic acid (DPA), DHA, EPA + DPA + DHA, linoleic acid, and arachidonic acid. Sleep duration (10 cohorts, n = 18,791) was categorized as short (≤6 h), 7-8 h (reference), or long (≥9 h). Difficulty falling asleep (8 cohorts, n = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling sleeping were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted ORs per quintile of PUFAs were pooled with inverse-variance weighted meta-analysis.

resultsIn pooled analysis adjusted for sociodemographic characteristics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. In the top compared with the bottom quintiles, the multivariable-adjusted ORs (95% CIs) for long sleep were 0.78 (95% CI: 0.65, 0.95) for DHA and 0.76 (95% CI: 0.63, 0.93) for EPA + DPA + DHA. Significant associations for ALA and n-6 PUFA with short sleep duration or difficulty falling sleeping were not identified.

conclusionsParticipants with higher concentrations of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relation. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.

Indexed as

Fatty AcidsFatty Acids, Omega-3BiomarkersCohort StudiesCross-Sectional StudiesHumansOutcome Assessment, Health CareSleepBiomarkersFatty AcidsFatty Acids, Omega-3biomarkersdietfatty acidsomega-3public healthsleep quality

Identifiers

PMID34918026
PMCPMC8895226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.