ArticleThe Lancet regional health. Europe2021
Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study.
Article in The Lancet regional health. Europe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The impact of adverse childhood experiences in the development of post-traumatic stress disorder in adults over 18 years of age: a systematic review.BMC psychiatry · 2025Pooled it
- Adverse childhood experiences and risk of late-life dementia: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- Association between questionnaire-based and accelerometer-based physical activity and the incidence of psychiatric disorders in people with loneliness or social isolation: findings from the UK Biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach.Translational psychiatry · 2026Article
- The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing.Journal of Alzheimer's disease : JAD · 2026Article
- The Neuroplastic Narrative and Neuro-Ecological Diversity: Non-Pathologizing Biological Foundations for Trauma-Informed Medical and Mental Health Nursing.International journal of mental health nursing · 2026Article
- Adverse Childhood Experiences and Life Course Adversity Related to Geriatric Syndromes: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Association of loneliness and social isolation with excess risk of mental disorders in people with obesity: a prospective cohort study.Population health metrics · 2025Article
- Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Adverse experiences in childhood and young adulthood, genetic susceptibility, and neurodegenerative disease incidence: a lifespan analysis.European journal of psychotraumatology · 2025Article
- Latent profile analysis of psychological abuse and neglect and the relationship with depression and anxiety: a multicentre cross-sectional study in western Chinese adolescents.European journal of psychotraumatology · 2025Article
- Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse middle-aged and older population.medRxiv : the preprint server for health sciences · 2025Article
- Childhood maltreatment, social connectedness, and depression: A prospective analysis of trajectories over time.Developmental psychology · 2025Article
- Association of active commuting with incidence of depression and anxiety: prospective cohort study.Translational psychiatry · 2025Observational
- Impact of post-traumatic stress disorder symptoms, childhood adversities and stressful life events on depressive and anxiety symptoms: insights from the UK Biobank.Frontiers in psychiatry · 2025Article
- Experiences of child abuse and prolonged grief in adulthood - results from a population-based study.Frontiers in psychiatry · 2025Article
- Adherence to the Healthy Low-Carbohydrate Diet and incident depression and anxiety.Frontiers in public health · 2025Article
- Early Life Stress and Major Depressive Disorder-An Update on Molecular Mechanisms and Synaptic Impairments.Molecular neurobiology · 2024Review
- History of childhood maltreatment associated with hospitalization or death due to COVID-19: a cohort study.BMC medicine · 2024Article
- A COVID-19 specific multiparametric and ECG-based score for the prediction of in-hospital mortality: ELCOVID score.Internal and emergency medicine · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundUnderstanding the mental health consequences of child maltreatment at different life stages is important in accurately quantifying the burden of maltreatment. This study investigated the association between child maltreatment and incident mental disorders in middle and older age as well as the potential mediators and moderators.
methodsThis is a retrospective cohort study of 56,082 participants from UK Biobank. Child maltreatment was recalled using the Childhood Trauma Screener. Incident mental disorders, including depressive, anxiety and affective disorders, behavioural syndromes, post-traumatic stress disorder (PTSD), schizophrenia, substance abuse, and dementia, after baseline assessment were ascertained through linkage to primary care records.
findingsThere was a dose-response relationship between child maltreatment and mental disorder. Those who experienced three or more maltreatment types had the highest risk of all mental disorders (HR 1.85, 95% CI: 1.67-2.06) followed by those who experienced two (HR 1.48, 95% CI: 1.35-1.63) and then one (HR 1.26, 95% CI: 1.19-2.35). Child maltreatment was most strongly associated with PTSD (HR 1.59, 95% CI: 1.20-2.10 P=0.001). The excess risk was largely unexplained by the included mediators. The association between child maltreatment and all mental disorders were stronger among participants who binge drank (P
interpretationThe mental health consequence of child maltreatment could last decades, even among those who had no recorded mental disorders in early adulthood. In the absence of strong mediators, prevention of child maltreatment remains the priority.
fundingWellcome Trust Institutional Strategic Support Fund.
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