ArticleJournal of veterinary research2021
Effect of Negative Energy Balance on Plasma Metabolites, Minerals, Hormones, Cytokines and Ovarian Follicular Growth Rate in Holstein Dairy Cows.
Article in Journal of veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Nutritional and phytogenic modulation of caprine physiology: a systematic review ofFrontiers in nutrition · 2026Pooled it
- Delayed ovulation in cattle: Physiological mechanisms, diagnostic approaches, and reproductive management strategies.Veterinary world · 2026Article
- Insulin-like growth factor 2 as a central regulator of growth and metabolic efficiency in livestock: Genetic, nutritional, and biotechnological perspectives.Veterinary world · 2026Review
- Impact of Nutrition on Embryo Production in Cattle: Mechanistic Insights.Animals : an open access journal from MDPI · 2026Review
- Comprehensive serum, follicular fluid, and ovarian tissue profiling reveals systemic metabolic alterations in high-yielding dairy cows with postpartum inactive ovaries.BMC veterinary research · 2026Article
- Long-acting progesterone supplementation and administration of gonadotropin releasing hormone in early diestrus improves pregnancy rates in Nellore cows with low body condition score and subjected to timed artificial insemination.Tropical animal health and production · 2025Article
- Ovarian follicular responses to estrus and ovulation synchronization protocols in East African Shorthorn Zebu cattle.Acta veterinaria Scandinavica · 2025Article
- Factors affecting follicular emergence at 10 days postpartum in lactating dairy cows.JDS communications · 2025Article
- Article
- Effect of body condition score loss during the transition period on metabolism, milk yield and health in Holstein cows.Journal of veterinary research · 2025Article
- Efficacy of Fat Supplements with Different Unsaturated/Saturated FA Ratios Undergoing First Postpartum Ovulation in Lactating Anovulatory Goats.Veterinary sciences · 2025Article
- The serum levels of triacylglycerols, nonesterified fatty acids, and beta-hydroxybutyrate as markers of reproductive capability of primiparous dairy cows.Journal of animal science · 2025Article
- Unravelling the Signature Follicular Fluid Metabolites in Dairy Cattle Follicles Growing Under Negative Energy Balance: An In Vitro Approach.International journal of molecular sciences · 2024Article
- Ultrasonographic Screening of Dairy Cows with Normal Uterine Involution or Developing Postpartum Uterine Disease Using B-Mode, Color, and Spectral Doppler.Veterinary medicine international · 2023Article
- Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows.Metabolites · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to evaluate the effect of negative energy balance (NEB) on the final growth of the dominant ovarian follicle in Holstein cows. MATERIAL AND
methodsCows at 14 to 21 d postpartum from an intensive dairy farm were randomly selected and allocated into a positive energy balance group (PEB, with β-hydroxybutyric acid (BHBA) level < 1.2 mmol/L, n = 15) and an NEB group (BHBA > 1.2 mmol/L, n = 15). Plasma samples were collected at 21, 50 and 55 d postpartum to assess the concentrations of energy metabolites, minerals, hormones and cytokines. Ovaries were examined by transrectal ultrasound on days 50 and 55 (120 hours later) to evaluate the diameter of the largest follicle.
resultsCompared with PEB cows, there were a more severe body condition loss and a lower milk yield in NEB cows (P < 0.05) and these had greater concentrations of plasma BHBA, non-esterified fatty acids, triglycerides, urea nitrogen, growth hormone, interleukin 6, and fibroblast growth factor 21 and lesser concentrations of plasma glucose, total cholesterol, insulin, insulin-like growth factor 1, insulin-like growth factor binding protein 3, leptin, brain-derived neurotrophic factor and angiopoietin-like protein 8 on d 21 (P < 0.05), while plasma minerals were not affected by energy status (P > 0.05). These changes persisted until the end of the study period (50-55 days postpartum) resulting in a lower follicular growth rate for cows in the NEB than the PEB group.
conclusionThese observations indicate that follicular growth rate is associated with measurable changes in energy metabolite, hormone and cytokine concentrations caused by early postpartum NEB.
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