ArticleImmunology1986
The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression.
Article in Immunology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Review
- Treatment and outcomes of primary mediastinal B cell lymphoma: a three-decade monocentric experience with 151 patients.Annals of hematology · 2021Observational
- Gene expression profiling of gray zone lymphoma.Blood advances · 2020Article
- Current Clinical Applications and Future Perspectives of Immune Checkpoint Inhibitors in Non-Hodgkin Lymphoma.Journal of immunology research · 2020Review
- Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.Frontiers in oncology · 2020Review
- Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.Blood · 2019Article
- How I treat primary mediastinal B-cell lymphoma.Blood · 2018Review
- Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R.British journal of haematology · 2017Article
- Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?Frontiers in immunology · 2015Review
- Article
- Article
- [Mediastinal large B-cell lymphoma].Der Pathologe · 2007Article
- Major histocompatibility complex class I and class II antigen expression in diffuse large cell and large cell immunoblastic lymphomas. Absence of a correlation between antigen expression and clinical outcome.The American journal of pathology · 1993Article
- Tumours of the thymus and their nomenclature.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Review
- HLA expression in human hepatocellular carcinoma.British journal of cancer · 1988Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eight cases of the recently reported 'primary mediastinal clear cell lymphoma of B-cell type' (Möller et al., 1986) were examined immunohistologically for the expression of cytoplasmic and/or surface antigens of MHC class I and II with mAbs directed against framework determinants of HLA-A,B,C (W6/32; B9.12.1), HLA-DP,DR,DQ (2.06), -DQ (Leu 10; Tü22), -DR (Tü34) gene products, and with mAbs specific for beta 2-microglobulin (BBM-1) and the HLA-D associated invariant chain (Vic-Y1). Besides the reported Ig-deficiency, the neoplastic B-cells of 7/8 tumours have variable defects in MHC antigen expression. Three lack both class I and class II antigens, one tumour lacks class I antigens but expresses HLA-DQ and -DR on the majority of neoplastic cells, three others contain varying proportions of MHC-antigen deficient tumour cells. The expression of Ii is closely correlated with HLA-D(R) expression and its antigenic sites are strictly located in the cytoplasm. Against the background of current knowledge, the variable and occasionally severe defects in MHC antigen expression within the herein presented series of B-cell lymphomas suggest that this unusual feature might be another characteristic of a novel lymphoma type.
Indexed as
Identifiers
3491784PMC1453200W2399438728What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.