ReviewClinical mass spectrometry (Del Mar, Calif.)2019
Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICS.
Review in Clinical mass spectrometry (Del Mar, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- The eternal struggle between titans: Fecal microbiota transplant (FMT) versus metformin in type 2 diabetes (T2D) gut dysmotility.Journal of advanced research · 2026Review
- Review
- Wise Roles and Future Visionary Endeavors of Current Emperor: Advancing Dynamic Methods for Longitudinal Microbiome Meta-Omics Data in Personalized and Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Article
- The Landscape and Perspectives of the Human Gut Metaproteomics.Molecular & cellular proteomics : MCP · 2024Article
- From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson's Disease Treatment?Cells · 2024Review
- Multiomics data integration, limitations, and prospects to reveal the metabolic activity of the coral holobiont.FEMS microbiology ecology · 2024Review
- Contigs directed gene annotation (ConDiGA) for accurate protein sequence database construction in metaproteomics.Microbiome · 2024Article
- Identification of Unambiguous Borrelia Peptides in Human Urine Using Affinity Capture and Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Biomarkers and computational models for predicting efficacy to tumor ICI immunotherapy.Frontiers in immunology · 2024Review
- Advanced computational tools, artificial intelligence and machine-learning approaches in gut microbiota and biomarker identification.Frontiers in medical technology · 2024Review
- Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron.Nature chemical biology · 2023Article
- Multi-omics analysis of fecal samples in colorectal cancer Egyptians patients: a pilot study.BMC microbiology · 2023Article
- Evaluating Current Molecular Techniques and Evidence in Assessing Microbiome in Placenta-Related Health and Disorders in Pregnancy.Biomolecules · 2023Review
- The Role of the Gut Microbiome in Cancer Immunotherapy: Current Knowledge and Future Directions.Cancers · 2023Review
- Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies.Chemical reviews · 2023Review
- Interrogating the role of the milk microbiome in mastitis in the multi-omics era.Frontiers in microbiology · 2023Review
- Current progress and critical challenges to overcome in the bioinformatics of mass spectrometry-based metaproteomics.Computational and structural biotechnology journal · 2023Review
- A bibliometric analysis of the global impact of metaproteomics research.Frontiers in microbiology · 2023Article
- Statistical Evaluation of Metaproteomics and 16S rRNA Amplicon Sequencing Techniques for Study of Gut Microbiota Establishment in Infants with Cystic Fibrosis.Microbiology spectrum · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our digestive tract hosts more than a billion microorganisms comprising non-pathogenic bacteria, viruses, fungi and parasites. Understanding and characterizing the human gut microbiota has become a fundamental common theme to establish a link between its dysbiosis and certain pathologies, especially autoimmune and inflammatory diseases. Meta-Omics studies have, so far, provided great progress in this field. Genomics is conventionally used to determine the composition of the microbiota and, subsequently, metatranscriptomics lists the transcribed genes. However, to better understand the relationship between microbiota and health, protein-based studies are being applied. Proteomics enables the functional study of proteins as they are expressed by microbial communities. Metaproteomics exploits the power of mass spectrometry to identify broad protein profiles in complex samples, such as gut microbiota. The lastest technological advances in the field of mass spectrometry have opened the field of large-scale characterization of microbial proteins. Despite these hardware improvements, bioinformatics analysis remains a primary challenge. Herein, we describe the state-of-the-art concerning specific sample preparation and powerful shotgun analysis techniques. We also review several scientific studies of the human gut microbiota. Moreover, we discuss the advantages and limitations encountered in this research area, concerning new methods of sample preparation and innovative bioinformatic tools. Finally, prospects are addressed regarding the application of metaproteomic in the field of clinical microbiology and its integration with other meta-Omics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.