ArticleFrontiers in oncology2021
The Impact of Preoperative and Postoperative Malnutrition on Outcomes for Ampullary Carcinoma After Pancreaticoduodenectomy.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Association of patient-generated subjective global assessment (PG-SGA) scores with survival outcomes in cancer patients: A systematic review and meta-analysis.Asia Pacific journal of clinical nutrition · 2026Pooled it
- Role of Oral Nutritional Supplements in Minimizing the Risk of Postoperative Malnutrition in Patients Undergoing Gastrointestinal Surgery.Journal of clinical medicine · 2026Article
- A systematic review of methodology in nutritional trials in patients undergoing pancreatoduodenectomy.Hepatobiliary surgery and nutrition · 2026Review
- Observational
- The relationship between preoperative hypoalbuminemia and postoperative subsyndromal delirium in elderly hip fracture patients: a prospective study.Frontiers in medicine · 2025Article
- The effects of sarcopenic obesity on immediate postoperative outcomes after pancreatoduodenectomy: a retrospective cohort study.Annals of surgical treatment and research · 2024Article
- Current postoperative nutritional practice after pancreatoduodenectomy in the UK: national survey and snapshot audit.BJS open · 2024Article
- Prognostic value of perioperative serum low-density lipoprotein cholesterol level for postoperative prognosis of pancreatic cancer: a retrospective study.Lipids in health and disease · 2023Article
- Review
- Tackling Surgical Morbidity and Mortality through Modifiable Risk Factors in Cancer Patients.Nutrients · 2022Review
- The Relationship between Phase Angle, Nutrition Status, and Complications in Patients with Pancreatic Head Cancer.International journal of environmental research and public health · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate the effect of preoperative and postoperative malnutrition on postoperative short- and long-term outcomes for ampullary carcinoma after pancreatoduodenectomy (PD).
methodsData were collected retrospectively from 511 patients with ampullary carcinoma who underwent PD between June 2012 and June 2019. Nutritional status before and at 3, 6, and 12 months after operation was assessed by the scored Patient-Generated Subjective Global Assessment (PG-SGA). The patients were classified into well-nourished, moderately malnourished, and severely malnourished group according to the PG-SGA score. Propensity score matching (PSM) was performed to adjust baseline characteristics between preoperative group A (well-nourished and moderately malnourished group) and group B (severely malnourished group). After PSM, clinicopathological variables and postoperative complications were compared between the two groups. Univariate and multivariate Cox analysis was also conducted to investigate the prognostic factors of overall survival of patients with ampullary carcinoma who underwent PD.
resultsPreoperatively, 122 (23.9%) patients were classified into well-nourished group, 189 (37.0%) into moderately malnourished group, and 200 (39.1%) into severely malnourished group. After PSM analysis, the incidence of overall postoperative complications was higher in group B than that in group A (50.5% vs. 32.5%, p < 0.001). Multivariate Cox proportional hazards regression model showed that severe malnutrition (PG-SGA score >9 scores) before operation [hazard ratio (HR) = 1.508; 95% CI, 1.103-2.061; p = 0.01] and at 6 months (HR = 4.148; 95% CI, 2.523-6.820; p < 0.001) and 12 months (HR = 5.272; 95% CI, 3.630-7.656; p < 0.001) after operation was an independent prognostic factor of patients who underwent PD for ampullary carcinoma.
conclusionsSevere malnutrition before and at 6 and 12 months after operation significantly affects the long-term survival of patients with ampullary carcinoma who underwent PD. Additionally, the preoperative malnutrition was closely related to postoperative complications.
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