Evidence map›Paper›PMID 34917429›Full record

ArticleCureus2021

Local Application of Transcutaneous Carbon Dioxide Paste Decreases Inflammation and Accelerates Wound Healing.

Rika Amano-Iga, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi

Open access · diamondAbstract read
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rika Amano-IgaOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Takumi HasegawaOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Daisuke TakedaOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Aki MurakamiOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Nanae YatagaiOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Izumi SaitoOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Satomi ArimotoOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Yasumasa KakeiOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Akiko SakakibaraOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Masaya AkashiOral and Maxillofacial Surgery, Kobe University Hospital, Kobe, JPN.
Kobe University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDelayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO

methodsForty-eight Sprague Dawley rats were randomized into control and CO

resultsRats in the CO

conclusionTaken together, the CO

Indexed as

angiogenesisblood flowhypoxiatranscutaneous co2wound healing

Identifiers

PMID34917429
PMCPMC8670822
OpenAlexW3213802017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.