Evidence map›Paper›PMID 34917372›Full record

ArticleClinical case reports2021

Confined placental mosaicism of trisomy 6 detected through genome-wide NIPT was associated with placental abruption.

Miyuki Nishiyama, Seiji Wada, Fuyuki Hasegawa, Yohji Uehara, Mamoru Ozaki, Kenichiro Hata, Yushi Ito, Haruhiko Sago

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miyuki NishiyamaCenter for Maternal-Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan.
Seiji WadaCenter for Maternal-Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan.ORCID https://orcid.org/0000-0002-8654-6623
Fuyuki HasegawaCenter for Maternal-Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan.
Yohji UeharaCenter for Maternal-Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan.
Mamoru OzakiDivision of Genomic Medicine, Department of Advanced Medicine Medical Research Institute, Kanazawa Medical University Ishikawa Japan.
Kenichiro HataDepartment of Maternal-Fetal Biology National Research Institute for Child Health and Development Tokyo Japan.
Yushi ItoCenter for Maternal-Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan.
Haruhiko SagoCenter for Maternal-Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Confined placental mosaicism (CPM) leads to discordant noninvasive prenatal testing (NIPT) results. We describe a very rare case of CPM of trisomy 6 detected through genome-wide NIPT. This case was associated with placental abruption, which might suggest an association between certain types of CPM detected by NIPT and pregnancy complications.

Indexed as

cell‐free DNAconfined placental mosaicismnoninvasive prenatal testingplacental abruptiontrisomy 6

Identifiers

PMID34917372
PMCPMC8645167

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.