Evidence map›Paper›PMID 34917298›Full record

ArticleBasic and clinical neuroscience

Glycine/NMDA Receptor Pathway Mediates the Rapid-onset Antidepressant Effect of Alkaloids From

Kennedy Kwami Edem Kukuia, Jeffrey Amoako Mensah, Patrick Amoateng, Dorcas Osei-Safo, Awo Efua Koomson, Joseph Torbi, Donatus Wewura Adongo, Elvis Ofori Ameyaw, Inemesit Okon Ben, Seth Kwabena Amponsah and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Kennedy Kwami Edem KukuiaDepartment of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu-Accra, Ghana.ORCID https://orcid.org/0000-0003-2948-9615
Jeffrey Amoako MensahDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, U.S. A.ORCID https://orcid.org/0000-0001-7026-9329
Patrick AmoatengDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.ORCID https://orcid.org/0000-0002-3607-6870
Dorcas Osei-SafoDepartment of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon-Accra, Ghana.ORCID https://orcid.org/0000-0001-7311-3485
Awo Efua KoomsonDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.ORCID https://orcid.org/0000-0001-7665-499X
Joseph TorbiDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.ORCID https://orcid.org/0000-0003-0944-9587
Donatus Wewura AdongoDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.ORCID https://orcid.org/0000-0002-1177-8729
Elvis Ofori AmeyawDepartment of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-8317-9602
Inemesit Okon BenDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.ORCID https://orcid.org/0000-0002-7752-3315
Seth Kwabena AmponsahDepartment of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu-Accra, Ghana.ORCID https://orcid.org/0000-0001-7411-0972
Kwasi Agyei BugyeiDepartment of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu-Accra, Ghana.ORCID https://orcid.org/0000-0002-9831-2349
Isaac Julius Asiedu-GyekyeDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.ORCID https://orcid.org/0000-0003-3902-5689
University of Ghana · GHKorle Bu Teaching Hospital · GHUniversity of Health and Allied Sciences · GHUniversity of Cape Coast · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMajor depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants. We previously reported that Alkaloids (ALK) from

methodsThe onset of ALK action from

resultsALK reversed immobility in mice after the second day of drug treatment in the OSST. In contrast, there was a delay in the effects induced by fluoxetine and imipramine. ALK also increased mean swimming and climbing scores in mice. ALK was more efficacious than imipramine and fluoxetine in reducing immobility and increasing distance traveled. It is noteworthy that ALK was less potent than fluoxetine and imipramine. D-cycloserine potentiated mobility observed in the ALK- and fluoxetine-treated mice. In contrast, D-serine decreased mobility in the ALK-treated mice.

conclusionThe study results suggest that ALK from

Indexed as

AlkaloidsGlycine/NMDA receptorOpen space swim testRapid-acting antidepressantTrichilia

Identifiers

PMID34917298
PMCPMC8666917
OpenAlexW3175973728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.