Evidence map›Paper›PMID 34917261›Full record

ArticleACS medicinal chemistry letters2021

Discovery of Imidazole-Based Inhibitors of

Rammohan R Yadav Bheemanaboina, Mariana Laureano de Souza, Mariana Lozano Gonzalez, Shams Ul Mahmood, Tyler Eck, Tamara Kreiss, Samantha O Aylor, Alison Roth, Patricia Lee, Brandon S Pybus and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Rammohan R Yadav BheemanaboinaDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Mariana Laureano de SouzaDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, 225 Warren Street, Newark, New Jersey 07103, United States.
Mariana Lozano GonzalezDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Shams Ul MahmoodDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Tyler EckDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Tamara KreissDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Samantha O AylorDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
Alison RothDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
Patricia LeeDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
Brandon S PybusDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
Dennis J ColussiMoulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.
Wayne E ChildersMoulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.
John GordonMoulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.
John J SiekierkaDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Purnima BhanotDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, 225 Warren Street, Newark, New Jersey 07103, United States.
David P RotellaDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.ORCID https://orcid.org/0000-0002-8224-218X
Montclair State University · USWalter Reed Army Institute of Research · USTemple University · USRutgers, The State University of New Jersey · US

Funding

Development of inhibitors of P. falciparum cGMP dependent protein kinase (PfPKG) for malaria chemopreventionR01AI133633 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI BHANOT, PURNIMA, ROTELLA, DAVID · 2017 to 2019
$2.1M
NIAID NIH HHS R01 AI133633
6 · The paper itself

Abstract

The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of

Identifiers

PMID34917261
PMCPMC8667308
OpenAlexW3213452177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.