Evidence map›Paper›PMID 34917233›Full record

ArticleOxidative medicine and cellular longevity2021

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice.

Toni Tamminen, Ali Koskela, Elisa Toropainen, Iswariyaraja Sridevi Gurubaran, Mateusz Winiarczyk, Mikko Liukkonen, Jussi J Paterno, Petri Lackman, Amir Sadeghi, Johanna Viiri and 3 more

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Toni TamminenDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.ORCID https://orcid.org/0000-0001-7932-3766
Ali KoskelaDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.ORCID https://orcid.org/0000-0003-1194-275X
Elisa ToropainenSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Iswariyaraja Sridevi GurubaranDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.ORCID https://orcid.org/0000-0003-1863-9550
Mateusz WiniarczykDepartment of Vitreoretinal Surgery, Medical University of Lublin, Poland.ORCID https://orcid.org/0000-0001-9704-3848
Mikko LiukkonenDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.ORCID https://orcid.org/0000-0002-4259-4041
Jussi J PaternoDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Petri LackmanEevia Health Oy, FI-60100 Seinäjoki, Finland.
Amir SadeghiSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Johanna ViiriDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Juha M T HyttinenDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.ORCID https://orcid.org/0000-0002-3414-4032
Ari KoskelainenDepartment of Neuroscience and Biomedical Engineering, Aalto University, FI-00067 Aalto, Finland.ORCID https://orcid.org/0000-0003-3842-8283
Kai KaarnirantaDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.ORCID https://orcid.org/0000-0003-2600-8679
University of Eastern Finland · FIAalto University · FIMedical University of Lublin · PLNorthern Ostrobothnia Hospital District · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age-related macular degeneration. We have previously shown an effective age-related macular degeneration disease model in mice with nuclear factor-erythroid 2-related factor-2 (NFE2L2) knockout. We have also shown pinosylvin, a polyphenol abundant in bark waste, to increase human retinal pigment epithelium cell viability

Indexed as

Oxidative StressAnimalsAntioxidantsApoptosisCell ProliferationCells, CulturedMiceMice, KnockoutNF-E2-Related Factor 2PhytoalexinsPlant ExtractsRetinal DiseasesStilbenesAntioxidantsNfe2l2 protein, mouseNF-E2-Related Factor 2PhytoalexinspinosylvinPlant ExtractsStilbenes

Identifiers

PMID34917233
PMCPMC8670936
OpenAlexW4200206099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.