Evidence map›Paper›PMID 34917230›Full record

ArticleOxidative medicine and cellular longevity2021

Repetitions of Strenuous Exercise Consistently Increase Paraoxonase 1 Concentration and Activity in Plasma of Average-Trained Men.

Aneta Otocka-Kmiecik, Monika Orłowska-Majdak, Robert Stawski, Urszula Szkudlarek, Piotr Kosielski, Gianluca Padula, Szymon Gałczyński, Dariusz Nowak

Open access · hybridAbstract read
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In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aneta Otocka-KmiecikDepartment of Experimental Physiology, Interfaculty Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.ORCID https://orcid.org/0000-0003-1696-4034
Monika Orłowska-MajdakDepartment of Experimental Physiology, Interfaculty Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.ORCID https://orcid.org/0000-0001-5501-2197
Robert StawskiDepartment of Clinical Physiology, Interfaculty Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.ORCID https://orcid.org/0000-0003-4164-4817
Urszula SzkudlarekDepartment of Experimental Physiology, Interfaculty Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.ORCID https://orcid.org/0000-0003-3113-3060
Piotr KosielskiAcademic Laboratory of Movement and Human Physical Performance, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland.ORCID https://orcid.org/0000-0002-9025-1852
Gianluca PadulaAcademic Laboratory of Movement and Human Physical Performance, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland.ORCID https://orcid.org/0000-0002-2748-9681
Szymon GałczyńskiAcademic Laboratory of Movement and Human Physical Performance, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland.ORCID https://orcid.org/0000-0002-3699-9704
Dariusz NowakDepartment of Clinical Physiology, Interfaculty Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.ORCID https://orcid.org/0000-0003-3445-6930
Medical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOxidative stress, induced by physical activity, may stimulate the expression, release, and activity of certain antioxidant enzymes. We investigated the effect of three repeated bouts of strenuous exercise on paraoxonase 1 concentration (PON1c) and paraoxonase activity (PON).

methodsEleven average-trained healthy men (age 34.0 ± 5.2 years) performed three strenuous exercise tests on a treadmill separated by 72 hours periods of resting. PON1c, PON, ferric-reducing activity of plasma (FRAP), lipid profile, C-reactive protein concentration (CRP), and lactate concentration were determined in plasma.

resultsEach exercise bout resulted in similar PON1c, PON, FRAP, and high-density lipoprotein concentration (HDL-C) increments, while PON/HDL-C ratio remained stable in all repetitions. Percentage increments at the bout of each exercise were higher for PON1c (by 64.82% at the first, by 92.9% at the second, and by 77.02% at the third exercise) than for PON (by 6.49% at the first, 10.06% at the second, and by 12.32% at the third exercise). Association was found between preexercise PON and PON1c (

conclusionsPON1c and PON increase during strenuous exercise, yet the effect of exercise on PON1 concentration is more pronounced. PON1 does not show tolerance to physical activity. The enzyme may provide short-term protection from oxidative stress in each exercise bout. PON may depend on exercise load. Cardiovascular fitness levels may be associated with PON1 activity.

Indexed as

ExerciseOxidative StressAdultAryldialkylphosphataseHumansMaleRestAryldialkylphosphatasePON1 protein, human

Identifiers

PMID34917230
PMCPMC8670925
OpenAlexW4200624040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.