Evidence map›Paper›PMID 34917176›Full record

ReviewTherapeutic advances in musculoskeletal disease2021

Consensus evidence-based recommendations for treat-to-target management of immunoglobulin A vasculitis.

Mohammed Hassan Abu-Zaid, Samia Salah, Hala M Lotfy, Maha El Gaafary, Hala Abdulhady, Samar Abd Alhamed Tabra, Hala Salah, Yomna Farag, Mervat Eissa, Sheren Esam Maher and 15 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in musculoskeletal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 2 countries.

Mohammed Hassan Abu-ZaidRheumatology and Rehabilitation, Tanta University, Tanta, Egypt.
Samia SalahPediatric Rheumatology, Cairo University, Cairo, Egypt.
Hala M LotfyPediatric Rheumatology, Cairo University, Cairo, Egypt.
Maha El GaafaryCommunity Medicine and Public Health, Ain Shams University, Cairo, Egypt.
Hala AbdulhadyRheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.
Samar Abd Alhamed TabraRheumatology and Rehabilitation, Tanta University, Tanta, Egypt.
Hala SalahPediatric Rheumatology, Cairo University, Cairo, Egypt.
Yomna FaragPediatric Rheumatology, Cairo University, Cairo, Egypt.
Mervat EissaRheumatology, Cairo University, Cairo, Egypt.
Sheren Esam MaherPediatric Rheumatology, Minia University, Minia, Egypt.
Ahmed RadwanRheumatology and Rehabilitation, Sohag University, Sohag, Egypt.
Amira Tarek El-ShanawanyRheumatology and Rehabilitation, Menoufia University, Shibin El Kom, Egypt.
Basma M MedhatRheumatology and Rehabilitation, Cairo University, Cairo, Egypt.
Dalia El MikkawyRheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.
Doaa Mosad MosaRheumatology, Mansoura University, Mansoura, Egypt.
Ghada El DerinyPediatrics, Alexandria University, Alexandria, Egypt.
Mohamed MortadaRheumatology and Rehabilitation, Zagazig University, Zagazig, Egypt.
Naglaa S OsmanPediatrics, Assiut University, Assiut, Egypt.
Nermeen Ahmed FouadRheumatology and Rehabilitation, Fayoum University, Fayoum, Egypt.
Nourhan Elameen ElkaralyRheumatology and Rehabilitation, Suez Canal University, Ismailia, Egypt.
Sally S MohamedRheumatology and Rehabilitation, Cairo University, Cairo, Egypt.
Waleed A HassanRheumatology and Rehabilitation, Benha University, Benha, Egypt.
Youmna A AmerRheumatology and Rehabilitation, Zagazig University, Zagazig, Egypt.
Samah Ismail NasefRheumatology and Rehabilitation, Suez Canal University, Ismailia, Egypt.
Yasser El MiedanyProfessor, Canterbury Christ Church University, Canterbury, England.ORCID https://orcid.org/0000-0002-4543-692X
Cairo University · EGAin Shams University · EGSuez Canal University · EGTanta University · EGZagazig University · EGAlexandria University · EGAssiut University · EGBenha University · EGFayoum University · EGMansoura University · EGMenoufia University · EGMinia University · EGSohag University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is the most common cause of systemic vasculitis in childhood. Given its potential life-threatening systemic complications, early and accurate diagnosis as well as management of IgAV represent a major challenge for health care professionals. This study was carried out to attain an evidence-based expert consensus on a treat-to-target management approach for IgAV using Delphi technique. The preliminary scientific committee identified a total of 16 key clinical questions according to the patient, intervention, comparison, and outcomes (PICO) approach. An evidence-based, systematic, literature review was conducted to compile evidence for the IgAV management. The core leadership team identified researchers and clinicians with expertise in IgAV management in Egypt upon which experts were gathered from different governorates and health centers across Egypt. Delphi process was implemented (two rounds) to reach a consensus. An online questionnaire was sent to expert panel ( PLAIN LANGUAGE SUMMARY: Given its potential life-threatening systemic complications, early and accurate diagnosis of immunoglobulin A vasculitis represents a major challenge for health care professionals. This work provided cornerstone principles for the management of the condition. Adopting PICO approach and implementing Delphi process a consensus was reached on evidence-based treat-to-target treatment recommendations. This will endorse enhancement and consistency of care of this cohort of patients in standard practice.

Indexed as

EgyptEgyptian guidelines IgA vasculitisguidelinesHenoch-Schönlein purpuraIgA vasculitisvasculitis algorithm

Identifiers

PMID34917176
PMCPMC8669874
OpenAlexW4200382611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.