Evidence map›Paper›PMID 34917097›Full record

ArticleFrontiers in immunology2021

Tcf1 Sustains the Expression of Multiple Regulators in Promoting Early Natural Killer Cell Development.

Juanjuan Liu, Zhao Wang, Shanshan Hao, Fang Wang, Yingpeng Yao, Yajiao Zhang, Yanyi Zhao, Wenhui Guo, Guotao Yu, Xiaohan Ma and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
    Review
  3. Integrative and deep learning-based prediction of therapy response in ovarian cancer.Journal of experimental & clinical cancer research : CR · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Juanjuan LiuState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhao WangState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Shanshan HaoState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Fang WangState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Yingpeng YaoState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Yajiao ZhangState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Yanyi ZhaoState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Wenhui GuoState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Guotao YuState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Xiaohan MaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Jingjing LiuState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Feng ChenCentral Laboratory, School of Stomatology, Peking University, Beijing, China.
Shunzong YuanDepartment of Hematology, the Fifth Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China.
Youmin KangState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Shuyang YuState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
China Agricultural University · CNPeking University · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell factor 1 (Tcf1) is known as a critical mediator for natural killer (NK) cell development and terminal maturation. However, its essential targets and precise mechanisms involved in early NK progenitors (NKP) are not well clarified. To investigate the role of Tcf1 in NK cells at distinct developmental phases, we employed three kinds of genetic mouse models, namely,

Indexed as

AnimalsAntigens, LyCell DifferentiationCells, CulturedGene Expression RegulationGranzymesHepatocyte Nuclear Factor 1-alphaKiller Cells, NaturalLymphocyte ActivationLymphocyte SubsetsLymphoid Progenitor CellsMiceMice, Inbred C57BLMice, KnockoutNatural Cytotoxicity Triggering Receptor 1T-Box Domain ProteinsAntigens, LyEomes protein, mouseGranzymesGzmb protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseT-Box Domain ProteinsdevelopmentmiceNK cellNKPtargetsTcf1

Identifiers

PMID34917097
PMCPMC8669559
OpenAlexW3217207248

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.