Evidence map›Paper›PMID 34917081›Full record

ArticleFrontiers in immunology2021

An HIV Vaccine Protective Allele in

Joy Ebonwu, Ria Lassaunière, Maria Paximadis, Mark Goosen, Renate Strehlau, Glenda E Gray, Louise Kuhn, Caroline T Tiemessen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Joy EbonwuDivision of Public Health Surveillance and Response, National Institute for Communicable Diseases, Johannesburg, South Africa.
Ria LassaunièreVirus Research and Development Laboratory, Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
Maria PaximadisFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mark GoosenFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Renate StrehlauEmpilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa.
Glenda E GrayPerinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Louise KuhnGertrude H. Sergievsky Centre, College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Caroline T TiemessenFaculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
University of the Witwatersrand · ZANational Institute for Communicable DiseasesColumbia University · USSouth African Medical Research Council · ZAStatens Serum Institut · DK

Funding

Host epigenetic and mitochondrial function in HIV-infected childrenR01HD073952 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2012 to 2016
$3.7M
Bone health in perinatally HIV-infected South African children on antiretroviralsR01HD073977 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPADI, STEPHEN M, YIN, MICHAEL T · 2012 to 2016
$3.6M
HIV Protective Immunity and Perinatal ExposureR01HD042402 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2002 to 2006
$3.1M
Clinical Relevance of Transient Nevirapine ResistanceR01HD047177 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2004 to 2008
$2.6M
HIV-1 chemoprophylaxis and archived drug resistance in infantsR01HD057784 · NICHD · JOHNS HOPKINS UNIVERSITY · PI PERSAUD, DEBORAH · 2007 to 2010
$2.3M
NICHD NIH HHS R01 HD042402NICHD NIH HHS R01 HD047177NICHD NIH HHS R01 HD057784NICHD NIH HHS R01 HD073952NICHD NIH HHS R01 HD073977
6 · The paper itself

Abstract

In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (

Indexed as

HIV-1Infectious Disease Transmission, VerticalAllelesCase-Control StudiesDNA Copy Number VariationsFemaleGenotypeHIV InfectionsHumansInfant, NewbornMalePolymorphism, Single NucleotideRandomized Controlled Trials as TopicReceptors, IgGFc gamma receptor IICReceptors, IgGFc gamma receptorFCGR2Cgene copy numbergenetic association studygenetic variantperinatal HIV-1 acquisitionpolymorphismSouth Africa

Identifiers

PMID34917081
PMCPMC8668943
OpenAlexW3216156985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.