Evidence map›Paper›PMID 34917075›Full record

ArticleFrontiers in immunology2021

The Immune Barrier of Porcine Uterine Mucosa Differs Dramatically at Proliferative and Secretory Phases and Could Be Positively Modulated by Colonizing Microbiota.

Deping Han, Peng Sun, Yanxin Hu, Jing Wang, Guoying Hua, Jianfei Chen, Chuyun Shao, Fan Tian, Hesham Y A Darwish, Yurong Tai and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Deping HanCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Peng SunResearch and Development Department for Breeding Poultry Feed, Shandong Hekangyuan Biological Breeding Co., Ltd, Jinan, China.
Yanxin HuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Jing WangCollege of Animal Science and Technology, China Agricultural University, Beijing, China.
Guoying HuaCollege of Animal Science and Technology, China Agricultural University, Beijing, China.
Jianfei ChenCollege of Animal Science and Technology, China Agricultural University, Beijing, China.
Chuyun ShaoCollege of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, China.
Fan TianCollege of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, China.
Hesham Y A DarwishDepartment of Applied Biotechnology, Molecular Biology Researches & Studies Institute, Assiut University, Assiut, Egypt.
Yurong TaiCollege of Animal Science and Technology, China Agricultural University, Beijing, China.
Xue YangCollege of Animal Science and Technology, China Agricultural University, Beijing, China.
Jianyu ChangCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Yunfei MaCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
China Agricultural University · CNNorthwest A&F University · CNAssiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial immune response is highly associated with the homeostatic balance of the uterus and embryo development; however, the underlying molecular regulatory mechanisms are not fully elucidated. Herein, the porcine endometrium showed significant variation in mucosal immunity in proliferative and secretory phases by single-cell RNA sequencing. The loose arrangement and high motility of the uterine epithelium in the proliferative phase gave opportunities for epithelial cells and dendritic cells to cross talk with colonizing microbial community, guiding lymphocyte migration into the mucosal and glandular epithelium. The migrating lymphocytes were primarily NK and CD8

Indexed as

AnimalsEndometriumEstrous CycleFemaleImmunity, MucosalMicrobiotaMucous MembraneSwinecell migrationintraepithelial lymphocytemacrophagemucosal immunityreproduction

Identifiers

PMID34917075
PMCPMC8670328
OpenAlexW3215056097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.