Evidence map›Paper›PMID 34917012›Full record

ArticleFrontiers in neurology2021

Characterizing the Neuroimaging and Histopathological Correlates of Cerebral Small Vessel Disease in Spontaneously Hypertensive Stroke-Prone Rats.

Yousef Hannawi, Eder Caceres, Mohamed G Ewees, Kimerly A Powell, Anna Bratasz, Jan M Schwab, Cameron L Rink, Jay L Zweier

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Hypertensive Brain Injury as a Journey Not a Destination.Journal of the American Heart Association · 2026
    Article
  5. Article
  6. Tobacco cigarette smoking induces cerebrovascular dysfunction followed by oxidative neuronal injury with the onset of cognitive impairment.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  7. Review
  8. Article
  9. MYPT1Translational stroke research · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease byJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yousef HannawiDivision of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University, Columbus, OH, United States.
Eder CaceresDivision of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University, Columbus, OH, United States.
Mohamed G EweesDivision of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
Kimerly A PowellDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, United States.
Anna BrataszSmall Animal Imaging Core, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
Jan M SchwabBelford Center for Spinal Cord Injury, The Ohio State University, Columbus, OH, United States.
Cameron L RinkDepartment of Neurosurgery, The Ohio State University, Columbus, OH, United States.
Jay L ZweierDivision of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
The Ohio State University · USAl-Azhar University · EG

Funding

Reducing Infection Susceptibility by Immune Function Restoration in Spinal Cord InjuryR01NS118200 · NINDS · OHIO STATE UNIVERSITY · PI SCHWAB, JAN · 2020 to 2024
$1.9M
NINDS NIH HHS R01 NS118200
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cerebral small vessel diseasemagnetic resonance imagingsensorimotor testingspontaneously hypertensive stroke prone ratWistar Kyoto Rat

Identifiers

PMID34917012
PMCPMC8669961
OpenAlexW3215104586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.